Functional brain network alterations in the prodromal phase of X-linked dystonia-parkinsonism
Objective: To determine whether functional connectivity changes are already present in non-manifesting carriers (NMCs) of the TAF1 gene mutation causing X-linked dystonia-parkinsonism (XDP). Background: XDP…A qualitative study exploring the feasibility of exergames among persons with Parkinson’s disease
Objective: The study aims to compare the usability of a newly developed exergame application designed for people with Parkinson’s disease (PD) to existing commercial games,…Subjective assessment of parkinson’s disease in relation to changes in brain microstructure
Objective: To elucidate the relationship between these subjective and objective ratings of PDQ-39 and the changes in brain microstructure. Background: PDQ-39 has been used to…Effectiveness of core muscle exercise training for Parkinson’s disease patients with trunk side-bending
Objective: To investigate the effect of core muscle exercise training on posture, balance, walking speed and walking quality in Parkinson's disease (PD) patients with trunk…The Blood-Brain Barrier Integrity and Prevalence of Intrathecal T Helper 17.1 Cells in Huntington´s Disease
Objective: The aim of the study was to investigate the potential role of cerebrospinal fluid (CSF)/plasma albumin quotient (Q-Alb) as a biomarker for blood-brain barrier…Efficacy of subthalamic nucleus deep brain stimulation in Parkinson’s disease: A preliminary Thailand experience
Objective: To evaluate the efficacy and adverse events of subthalamic nucleus deep brain stimulation (STN-DBS) in Thai patients with Parkinson’s disease (PD). Background: Bilateral STN-DBS…Consanguinity is the key player in complexity of Mendelian form of neurodegeneration with brain iron accumulation in Pakistan
Objective: In the current work, we recognized big inbreed Pakistani family with autosomal recessive NBIA containing several affected individuals. Aim of the research work was…Adult onset neuronal Intranuclear Inclusion Disease (NIID) which initially presented with gait imbalance and fall
Objective: To report a rare case of adult onset neuronal intranuclear inclusion disease (NIID) presented with gait disturbance and fall, and finally confirmed with skin…Deep brain stimulation and fusion technologies: a synthesis study
Objective: The major thrust is analyzing the large amounts data computationally generated and synthesizing it into useful systems-wide models of biological processes. Background: It is…Preparing for a clinical trial: a run-in natural history study in POLR3A-associated spastic ataxia with intronic mutations amenable to splice-modulating therapeutic approaches
Objective: The aim of this study is the identification of progression and treatment response outcomes for POLR3A-associated spastic ataxia caused by the recurrent intronic c.1909+22G>A…
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