In-vivo free-water imaging and functional connectivity in a knock-in mouse model of DYT1 dystonia
Objective: To examine in-vivo functional connectivity and free-water diffusion imaging in dystonic mutant Tor1a knock-in (DYT1) and wild-type (WT) control mice. We test the hypothesis…Assessing vestibular function in individuals with cervical dystonia and the effects of botulinum toxin treatment
Objective: To determine if individuals with cervical dystonia have altered vestibular function compared to unaffected individuals, and whether botulinum toxin treatment alters those variables. Background:…Differences in processing proprioceptive input from the neck muscles may explain the benefit from sensory tricks in patients with idiopathic cervical dystonia
Objective: We used a paradigm of neck vibration to test the hypothesis that the sensory trick (ST), which is used by some patients with idiopathic…Striatal postsynaptic dysfunction in X-linked dystonia-parkinsonism is associated with disease progression
Objective: To assess pre- and postsynaptic dopaminergic function in X-linked dystonia-parkinsonism (XDP). Background: X-linked dystonia-parkinsonism (XDP) is a neurodegenerative adult-onset movement disorder associated with striatal…Multi-parameter imaging in hemidystonia responsive to GPi deep brain stimulation
Objective: To present i) imaging data in a case of hemidystonia using structural (diffusion tensor imaging-DTI and fiber tractography-FT) and functional (functional MRI-fMRI and magnetoencephalography-MEG)…Chewing-induced blepharospasm in Parkinson’s disease
Objective: Report and discuss a rare presentation of BS. Background: Dystonia is described in untreated Parkinson's disease (PD) patients and is also one of the…Real-time ultrasound for automated analysis and visualization of neck muscles in cervical dystonia
Objective: To demonstrate an automated ultrasound-based method for real-time visualization of neck muscles in cervical dystonia. Background: Understanding of the pattern and extent of muscle…The sense of agency is altered in cervical dystonia
Objective: We investigated whether deficits in motor representation are associated with alterations of the sense of agency in dystonic patients. Background: Abnormalities of the cognitive…Temporal dynamics of pallidal low-frequency oscillations in dystonia
Objective: To assess the occurrence and volatility of 4-12 Hz oscillations in local field potentials (LFPs) recorded in the internal globus pallidus (GPi) of dystonia…Therapeutic potential of compounds preferring specific GABAA receptor subunits for the treatment of dystonia?
Objective: To further define the pathophysiology of the reduction of striatal interneurons in an animal model of dystonia and to develop novel therapeutic strategies targeting…