Stabilometry characteristics as objective Parkinson’s disease progression biomarkers
Objective: We aimed to find stabilometry characteristics, which may be used as disease progression and postural instability early development markers. Background: Balance and gait disorders…Generation and characterization of midbrain organoids from iPSCs of familial Parkinson’s disease
Objective: To generate and characterize human pluripotent stem cell (iPSCs) - derived midbrain cerebral organoids of patients with Parkinson's disease. Background: Parkinson's disease is a…Cyclic glycine-proline increased in the cerebrospinal fluid of Parkinson’s patients after supplementation of blackcurrant anthocyanins: Potential biomarker for treatment
Objective: We evaluated the changes of insulin-like growth factor-1 bioavailability in the Parkinson's disease patients after 28 day supplementation of blackcurrant anthocyanin. Background: Elevated insulin-like…In idiopathic Parkinson’s disease: The effect of using L-dopa on peripheral nerves
Objective: Idiopathic Parkinson's disease (IPD) is a chronic neurodegenerative disorder. Most of the clinicians believe that it is limited with motor and cognitive disorders. However,…Cortical role in the freezing of gait in Parkinson’s disease
Objective: In this study, we aimed to investigate the neural underpinning of freezing of gait (FOG) in Parkinson's disease (PD), especially the role of the…Association of Parkinson’s disease severity and cortical and subcortical cognitive markers
Objective: To assess cortical and subcortical dysfunction in several stages of Parkinson's disease (PD) using the Parkinson's disease-cognitive rating scale (PD-CRS). Background: Cognitive impairment in…Pathophysiological mechanisms of bone mass loss for osteoporosis prevalence in Parkinson’s disease
Objective: Quantify the impact of osteoporosis in Parkinson's disease to know factors that caused bone loss. Background: Parkinson´s disease (PD) and osteoporosis are two conditions…Glutathione status in Parkinson’s disease
Objective: Describe measures of glutathione (GSH) status in a cohort of individuals with Parkinson's disease (PD). Background: It is well established that redox stress contributes…Intrastriatal injection of ionomycin profoundly changes motor response to L-DOPA and its underlying molecular mechanisms
Objective: We investigated whether intrastriatal injection of ionomycin to hemiParkinsonian rats produced changes in L-DOPA responses including LID and analyzed the effects of ionomycin on…Lrrk2 alleles modify host response to microbial infections
Objective: The mechanisms by which allelic changes in LRRK2 modulate the susceptibility to Parkinson's disease, Crohn's disease and leprosy remain unknown. We hypothesized that leucine-rich…