Clinical and biological predictors of excessive daytime sleepiness in early Parkinson’s disease
Objective: To examine longitudinal change in excessive daytime sleepiness (EDS) and to determine clinical and biological variables that predict new onset EDS in the cohort…Frequency and characteristics of diplopia in non-demented patients with Parkinson’s disease
Objective: To assess the frequency of diplopia and its relation to motor and non-motor symptoms in a cross sectional sample of non-demented patients with idiopathic…Dopamine transporter, depression and anxiety differences between tremor-predominant and non-tremulous PD are already evident within 2 years of PD diagnosis
Objective: PD patients can be partitioned into two groups, denoted Tremor Dominant (PD-TD) and non-tremor-dominant (PD-NTD) based on their MDS-UPDRS III subscores. Is this distinction…Neurocognitive domains of impulsivity in Parkinson’s disease (PD) and the effects of dopaminergic replacement therapy (DRT)
Objective: To investigate whether 3 different domains of impulsive behavior(reactive, proactive and cognitive) are differentially affected in medicated PD as compared with healthy controls. We…Neuropsychological assessment in the Luxembourg Parkinson’s cohort (HELP-PD)
Objective: To report first results on the prevalence of cognitive non-motor symptoms in the Luxembourg Parkinson's cohort (HELP-PD). Background: HELP-PD aims to combine thorough assessment…First documented case of burning mouth syndrome (BMS) responsive to levodopa-carbidopa intestinal gel (LCIG) infusion in Parkinson’s disease (PD)
Objective: To report a PD patient with severe BMS refractory to different medications with significant improvement from LCIG infusion. Background: BMS is an often distressing…Speech evaluation in Parkinson’s disease using a transcribed version of the Frenchay dysarthria assessment
Objective: To assess the usefulness and metric properties of a transcribed version of the Frenchay Dysarthria Assessment 2 (FDA-2) for speech evaluation in a cohort…Identification of premotor Parkinson’s disease
Objective: To evaluate the prevalence of and associations between potential markers of premotor Parkinson's disease (PD) and to estimate the relative risk of these markers…Allele specificity in neurodegenerative olfactory dysfunction
Objective: Assess olfactory dysfunction in carriers of the p.N279K and p.P301L MAPT mutations, which cause FTDP-17, to understand how genotypic differences contribute to the severity…Fundamental differences in Parkinsonian rat limbic regions contribute to anxious behavior and diminished responsiveness to diazepam
Objective: To (1) examine whether anxiety-like behavior is more prevalent in Parkinsonian compared to non-Parkinsonian rats, (2) evaluate the efficacy of diazepam in Parkinsonian and…