Frontal-subcortical cognitive impairments in Parkinson’s patients with freezing of gait
Objective: To evaluate the relationship between frontal-subcortical cognitive dysfunctions and freezing of gait (FOG) in Parkinson's disease (PD). Background: FOG is a complex and multisystem…Molecular Genetics and Functional Studies of LRRK2 Gene Variations in Parkinson’s Disease
Objective: To evaluate the function role of ROC domain in the brains of LRRK2 transgenic mice model and normal control mice. Background: Mutations in leucine-rich…Role of microglia in the transmission of α-syn-containing exosomes
Objective: we investigated the role of microglia in the transmission of α-syn-containing exosomes and offer a new insight into the mechanism of PD pathogenesis. Background:…The difference in posture reaction against backward perturbation between patients with Parkinson’s disease and healthy controls
Objective: To investigate the posture reaction in patients with Parkinson’s disease (PD) and healthy age-matched controls when they were given quantitative backward perturbation. Background: Although…Apathy in Parkinson’s disease is associated with abnormal alpha oscillatory behaviour during incentivized movement
Objective: To determine the relation between apathy and neural oscillations in Parkinson’s disease (PD). Background: Apathy in PD, characterized by lack of motivation, is often…B lymphocytes may be protective in early Parkinson’s disease and in an animal model of dopaminergic cell death
Objective: To investigate B lymphocyte phenotype and function in human PD and in an animal model of disease. Background: The clinical course in Parkinson’s disease…Unveiling the function of altered gut microbiota composition in Parkinson’s disease
Objective: To investigate the gut microbiome and metabolome in Parkinson’s disease (PD). Background: Recent evidence revealed that gut microbes promote alpha-synuclein pathology and motor deficits…Predictors of freezing of gait in newly diagnosed Parkinson’s disease: Clinical, dopamine transporter imaging and CSF markers in the PPMI cohort
Objective: To examine whether clinical, dopamine transporter (DAT) imaging and cerebrospinal fluid (CSF) markers can be used to predict the later development of FOG individually…α-synuclein aggregation and propagation in marmoset brains deteriorates its motor function
Objective: To confirm that α-synuclein aggregation and propagation in marmoset brains deteriorates its motor function. Background: Recently, the α-synuclein amyloid fibril is thought to be…Pharmacological modulation of lysosomal glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson’s disease
Objective: To study the pharmacological modulation of glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson's disease (PD). Background: PD is a complex neurodegenerative disorder…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.