Digitally captured Archimedes spiral indices correlate with clinical assessment of dystonia severity
Objective: To determine whether digitized spiral analysis captures severity of dystonia in comparison to motor scores from the clinical gold standard, the Burke-Fahn-Marsden rating scale…Exome sequencing reveals homozygous mutations in SACS, ATCAY, and MCOLN1 in three Pakistani families with complex dystonia
Objective: To elucidate the genetic cause in Pakistani families with recessively inherited disorders with dystonic features. Background: Dystonia is a movement disorder characterized by sustained…Seated balance is impaired in patients with idiopathic cervical dystonia
Objective: To investigate whether seated balance is impaired in patients with idiopathic Cervical Dystonia (CD). Background: Idiopathic CD is a movement disorder in which involuntary…Impaired response times to luminance stimuli in dystonia patients indicate disordered superior colliculus processing
Objective: We hypothesise that patients with adult onset isolated focal dystonia (AOIFD) will have slower reaction times to luminance stimuli versus healthy controls due to…A dynamic causal model of the superior colliculus: Inhibitory activity increases with the temporal discrimination threshold
Objective: To investigate if abnormalities observed in the putamen of unaffected first-degree relatives (of cervical dystonia patients) with abnormal temporal discrimination thresholds (TDT) are a…Investigation of head tremor in cervical dystonia: Novel application of virtual reality head mounted display, the oculus rift
Objective: We aim to characterise tremulous head movements in cervical dystonia during eccentric left- and right-going head rotations. Background: Cervical dystonia is the most common…Mental simulation of whole-body movements in patients with isolated cervical dystonia
Objective: To explore mental transformation of whole-body images in patients with isolated cervical dystonia (CD). Background: Mental transformation of bodies or of body-part images is…Dystonia, tremor, and dystonic tremor
Objective: To provide guidance for current debates regarding the nosology of tremor in dystonia. Background: Dystonia is defined as a disorder with sustained or intermittent…Abnormal motor sequence representation in dystonia
Objective: To identify behavioral differences of motor sequence representation in persons with dystonia. Background: Dystonia is a movement disorder characterized by variable twisting postures and…Predictors of onabotulinumtoxinA treatment response in patients with cervical dystonia
Objective: Data from CD PROBE (Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy), an observational, multicenter, prospective clinical registry, were analyzed to try to…