Clinical, radiological and genetic spectrum of fifteen cases of PLA2G6-Associated Neurodegeneration – A Single Centre Cohort from India
Objective: To study the clinical, radiological and genetic profile of patients with genetically proven PLA2G6-Associated Neurodegeneration (PLAN). Background: PLAN is a clinically heterogenous genetic disorder…Tourettism occurring during gender transition with testosterone therapy
Objective: Past decades have seen an increase in gender dysphoria subjects seeking hormonal treatment1,2. We report motor and vocal tics following testosterone therapy introduction for…Arm swing deviations in patients with PD at different gait velocities
Objective: To assess bilateral arm swing (AS) and other gait parameters in patients with PD and healthy subjects (HS) at various gait speeds and to…Free water neuro-imaging changes as the biomarker in new diagnosis of Wilson’s disease
Objective: The bi-tensor free water imaging may provide more specific information in detecting microstructural brain tissue alterations than conventional single tensor diffusion tensor imaging. The…18F-Florzolotau PET Imaging Captures the Distribution Patterns and Regional Vulnerability of Tau Pathology in Progressive Supranuclear Palsy
Objective: This study aimed to investigate whether 18F-Florzolotau PET imaging may capture the distribution patterns and regional vulnerability of tau pathology in PSP, and to…The epigenetic association of Parkinson’s disease risk gene- GPNMB rs199347 with drinking
Objective: This paper examines the epigenetic association of rs199347 polymorphism variants of the GPNMB with drinking and DNA methylation changes. Background: Neuroinflammatory response induced by alcohol…Effect of ADX-88178, a highly-selective mGlu4 PAM, on parkinsonism, dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset
Objective: To investigate the effect of the metabotropic glutamate 4 (mGlu4) positive allosteric modulator (PAM) ADX-88178 on parkinsonism, dyskinesia and psychosis-like behaviours (PLBs) in the…Effect of the 5-HT2A/2C inverse agonist nelotanserin on dyskinesia in the MPTP-lesioned marmoset
Objective: To determine the effect of the serotonin 2A/2C (5-HT2A/2C) receptor inverse agonist nelotanserin on dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset. Background: Nelotanserin is a…Effects of exergaming-based tai chi and eye movement training on balance and gait in progressive supranuclear palsy: a case report
Objective: To evaluate the effectiveness of exergaming-based tai chi and eye movement training in improving functional balance, gait and quality of life in a patient…Improved Tremor Response to Focused Ultrasound Thalamotomy
Objective: This study sought to determine if, when using four tract tractography (FTT) to target the decussating and non-decussating dentatorubrothalamic tracts (DRTTs), essential tremor (ET)…
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