Strategies for a high quality data in an observational longitudinal study: Enroll-HD experience
Objective: To describe results of a combined risk-based monitoring (RBM) approach in the context of a large global observational longitudinal study, Enroll-HD. Background: Enroll-HD is…Evaluating swallowing function in patients with Huntington disease enrolled in the first-HD study
Objective: The Swallowing Disturbance Questionnaire (SDQ) was administered to patients with Huntington disease (HD) as part of a randomized, controlled study of deutetrabenazine for the…Clinical and behavioral features in carriers of intermediate length alleles of HTT gene. A case series of Mexican population
Objective: To describe clinical manifestations in carriers of intermediate alleles (IAs) of CAG trinucleotides in HTT gene of Mexican population. Background: Huntington's disease (HD) is…A health cost analysis for Huntington disease in Peru
Objective: To estimate economic costs of caring for an individual with Huntington disease from the patients and caregivers perspective. Background: Huntington disease (HD) is a…Psychosis in Huntington’s disease
Objective: To describe the characteristics and phenomenology of psychotic symptoms in a Spanish cohort of HD patients. Background: Neuropsychiatric features are characteristic symptoms in Huntington's…THK-5351 tau-tracer uptake in patients with clinically diagnosed progressive supranuclear palsy
Objective: The objective of our study is to investigate characteristics of THK-5351 binding in patients with clinically diagnosed progressive supranuclear palsy (PSP) and correlate tau-tracer…Verbal fluency deficits in essential tremor patients: Underlying structural changes
Objective: A disturbance of verbal fluency (VBF) in essential tremor patients compared to healthy controls is well described. The underlying structural alterations that a causative…Brain network imaging findings in multiple system atrophy with cognitive decline
Objective: In this study we examined the voxel-based morphometry (VBM), diffusion tensor imaging (DTI), and resting functional MRI (rsfMRI) of the multiple system atrophy (MSA)…Assessment of subclinical cerebellar involvement in progressive supranuclear palsy using SUIT based volumetric analysis
Objective: To explore the pattern of cerebellar atrophy if any, in patients with Progressive Supranuclear Palsy (PSP) using the SUIT (Spatially Unbiased atlas template for…Three-dimensional cytoarchitecture of the basal ganglia: Clinical applications of a computational pipeline for histology to MRI registration
Objective: Use modified histological techniques and a computational registration pipeline to delineate accurately post-operative 3D basal ganglia anatomy in DBS implants. Background: Stereotaxy is based…