Istradefylline effect on Parkinson’s Disease Tremor, Motor symptoms and non-Motor symptoms.
Objective: Istradefylline is FDA approved for use in patients with PD treated with carbidopa-levodopa to reduce off time. GUH Movement Disorder Group has observed that…Effort-based decision-making and neuropsychiatric symptoms before and after subthalamic nucleus deep brain stimulation in Parkinson’s disease
Objective: Parkinson’s disease patients with apathy and patients in the medication OFF state show reduced reward sensitivity in effort-based decision-making tasks. The effect of subthalamic…A network imaging biomarker of X-linked dystonia-parkinsonism
Objective: To characterize a metabolic brain network associated with X-linked dystonia-parkinsonism (XDP). Background: X-linked dystonia-parkinsonism (XDP, DYT/PARK-TAF1, Lubag) is an X-linked recessive movement disorder characterized…Does fatigue in Parkinson’s disease impact one’s physical function in daily live?
Objective: To investigate fatigue at baseline and 3.5 years later and its association with balance and gait over time. Background: In Parkinson’s disease (PD), fatigue…Levodopa-induced dyskinesia and Huntington’s chorea: link to current motor control theories
Objective: Determine if there is a motor control hypothesis that could explain movement kinematics of Huntington’s disease (HD) chorea and Parkinson’s disease (PD) levodopa-induced dyskinesia…A Phase 2, Double-blinded, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of ABP-450 (PrabotulinumtoxinA) in Adults with Isolated Cervical Dystonia
Objective: To evaluate the safety and the efficacy of ABP-450 (prabotulinumtoxinA) in patients with cervical dystonia (CD). Background: ABP-450 (prabotulinumtoxinA) is a new 900kDA botulinumtoxinA.…Dance for Parkinson’s disease to improve gait and balance: clinical assessments vs. objective measures.
Objective: To evaluate how the dance classes based on the Dance for Parkinson’s Disease®(DfPD®) model could improve gait and balance in people with Parkinson’s disease…Cortical mean diffusivity and cortical thickness in essential tremor
Objective: To study the cortical microstructure in ET patients Background: Essential tremor (ET) is a common movement disorder, but the pathogenesis is poorly understood. Several…Identification of pre-frailty in the elderly through serum metabolomics and its impact on Parkinson’s disease phenotype
Objective: We attempted to better characterize pre-frailty using serum metabolomics in a large cohort of elderly subjects without neurodegenerative diseases. Next, we sought to investigate…Dysphagia in Parkinson’s disease
Objective: To evaluate the presence of dysphagia in patients with Parkinson Disease (PD) and determine associated factors and possible clinical predictors. Background: Parkinson's disease (PD)…
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