Drivers of longitudinal healthcare cost in Parkinson Disease
Objective: To identify associations between baseline patient and disease characteristics, and longitudinal healthcare costs in Parkinson disease (PD). Background: Disease prevalence, disability-adjusted life-years, and PD…A phase 2 randomized, double-blind, placebo-controlled trial of Ambroxol as a disease-modifying treatment for Parkinson’s disease dementia.
Objective: To evaluate the safety and tolerability of repurposing Ambroxol as a disease modifying treatment for Parkinson’s Disease Dementia (PDD). Background: Carrying a mutation in…Analysis of the therapeutic potential of c-Abl inhibition in Multiple System Atrophy
Objective: IkT-148009 is a potent selective inhibitor of non-receptor Abelson Tyrosine Kinases (c-Abl kinases). Our recent analysis of post-mortem brain tissue from patients with Multiple…A 20-year review of a Movement Disorders Database in Singapore
Objective: To conduct a 20-year review of the movement disorders (MD) clinical database in Singapore. Background: MDs contribute to a significant portion of chronic disease…Effect of dietary caffeine on brain dopamine transporter binding in Parkinson’s disease
Objective: To investigate the relationship between dietary caffeine intake and striatal dopamine function over the progression of Parkinson’s disease (PD). Background: The association between high…Consanguinity is the key player in complexity of Mendelian form of neurodegeneration with brain iron accumulation in Pakistan
Objective: In the current work, we recognized big inbreed Pakistani family with autosomal recessive NBIA containing several affected individuals. Aim of the research work was…Does fatigue in Parkinson’s disease impact one’s physical function in daily live?
Objective: To investigate fatigue at baseline and 3.5 years later and its association with balance and gait over time. Background: In Parkinson’s disease (PD), fatigue…Selegiline drives autophagic secretion of α-synuclein
Objective: Our aim is to elucidate how selegiline drives extracellular secretion of α-synuclein (αS) and whether selegiline-induced αS secretion affects cell-to-cell transmission of αS. Background:…Globus pallidus interna deep brain stimulation for Parkinson’s Disease: Impact on Restless Legs Syndrome
Objective: The goal of this study was to evaluate the impact of deep brain stimulation (DBS) of the globus pallidus interna (GPi) on Restless Legs…Clinic versus home dose optimization of apomorphine sublingual film in Parkinson’s Disease: cross-study comparison of safety
Objective: To compare the safety profile of clinic versus home dose optimization of apomorphine sublingual film (SL-APO) in patients with Parkinson’s disease experiencing OFF episodes.…
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