Automated immunohistochemical detection of pathological alpha-synuclein in human tissue biopsy
Objective: The goals of this study were to create a highly sensitive brightfield immunohistochemical (IHC) assay for pathological alpha-synuclein (aSyn) in formalin-fixed, paraffin embedded (FFPE)…Natural occurring antibodies reduce aggregation of α-synuclein
Objective: We tested naturally occurring antibodies (nAbs) against α-synuclein both in vitro as well as in HEK293T cells to determine binding, cell viability and capacity…Peripheral Inflammatory Mediators in Parkinson’s Disease – A Potential Biomarker
Objective: i.To determine if post-translationally modified phosphorylated α-synuclein levels are altered in the peripheral blood of Parkinson’s disease (PD) patients compared to control subjects. ii.To…A metabolomic signature of treated and drug-naïve patients with Parkinson disease: A pilot study
Objective: The aim of our case–control study is to compare entire blood metabolomic profiles obtained from treated PD patients, de novo PD patients and controls,…α-synuclein antibody 5G4 identifies manifest and prodromal Parkinson’s disease in colonic mucosa
Objective: The aim of this study was to evaluate colonic mucosa staining using the 5G4 antibody, specific only for the disease-associated form of α-synuclein, in…Dietary habits, motor and cognitive impairment in Parkinson’s Disease
Objective: To evaluate the relationship between dietary habits, motor and cognitive impairment in Parkinson's disease patients with both cross-sectional and longitudinal design Background: Diet and…Saccades in Parkinson’s disease: Hypometric, slow, or maladaptive?
Objective: Quantitatively study visually-guided saccades (VGS) in Parkinson’s disease (PD). Background: Visuomotor deficits such as hypometric VGS are present in PD despite the retained ability…Modulation of CaMKIIa-NR2B interaction in levodopa-induced dyskinesia in 6-OHDA- lesioned Parkinson’s rats
Objective: In the present study, therefore, we examined the relationship between CaMKII and NR2B in levodopa-induced dyskinesia rats. Background: Long-term treatment with L-dopa leads to…Alpha-synuclein oligomer and rotenone treatments injury the dopaminergic neuron via inhibiting the expression of gene SEMA6D
Objective: To investigate the expression of Semaphorin6D (SEMA6D) and its interaction with Plexin-A1 in cellular Parkinson's disease(PD) models induced by α-synuclein and rotenone. Background: In…Neuropathological correlates of psychiatric disorders in PD
Objective: To test the hypothesis that neuropsychiatric symptoms (NPS) in PD are associated with histopathologically confirmed neuronal loss and gliosis (NLG) in the locus coeruleus…