Cell and animal models lacking RAB39B show biochemical and behavioural phenotypes that model aspects of Parkinson’s disease
Objective: To determine the pathogenic mechanisms underlying RAB39B-mediated Parkinson’s disease (PD). Background: PD is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the…Pupil evaluation as the test for the clinical manifestations of Parkinson’s disease
Objective: We clarify the correlation between abnormality in 123I-metaiodobenzylguanidine (MIBG) scintigraphy and task-evoked pupillary response in Parkinson's disease (PD) patients. Background: MIBG scintigraphy is one…The increased α-syn expression inhibits exosomal secretion
Objective: Exosomes, nano-sized extracellular vesicles, play an important role in many physiological processes in the central nervous system. Recently, we and others have demonstrated that…The Association between Infections and Parkinson Disease: A Systematic Review and Meta-analysis
Objective: Our study aimed to recapitulate and summarize the findings from the literature to provide an overview on the correlation between infection and PD. Background:…Neurophysiological correlates of bradykinesia in Parkinson’s disease
Objective: In the present study we aimed to investigate whether objective measures of bradykinesia in Parkinson’s disease have any relationship with neurophysiological measures in primary…Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice
Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…Multisite Tissue and Biofluid Sampling for Alpha-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Objective: To characterize the distribution of alpha-synuclein (aSyn) pathology in multiple tissues and body fluids within the same Parkinson’s disease (PD) subjects and compared to…Insulin degrading enzyme, a novel key protein against alpha-synuclein oligomers formation?
Objective: The objective of this work is to study the interaction between α-synuclein and the insulin degrading enzyme in the pancreas of subjects with synucleinopathies.…Salivary Alpha-Synuclein a new tool for the diagnosis of Parkinson’s disease?
Objective: The aim of the PARKSYN study was to test the utility of salivary alpha-synuclein (a-syn) concentration in the differential diagnosis between Parkinson's disease (PD)…Decreased amyloid-beta in patients with Idiopathic Parkinson’s Disease and white matter hyperintensities
Objective: The aim of this study is to investigate the clinical and biochemical profile of patients with PD with and without WMH. Background: Parkinson’s disease…