A case of levodopa responsive rapid onset dystonia-parkinsonism
Objective: We describe and demonstrate by video a young man with rapid onset dystonia parkinsonism who has a robust response to levodopa. Background: Rapid onset…Oculomotor Behavior in Healthy Caribbean: Does it reflect an increased vulnerability to degenerative Parkinsonism?
Objective: To investigate the impact of environmental factors on eye movement performances in two populations composed of carefully selected healthy subjects with strikingly different ethnic…Spatial correlation and segregation of multimodal MRI abnormalities in multiple system atrophy
Objective: This study aimed to quantify spatial patterns of multimodal MRI abnormalities in basal ganglia (BG) and brainstem-cerebellar (Stem-CB) regions and define structural MRI findings…Revision of Diagnosis in Early Parkinsonism with Abnormal Dopamine Transporter Imaging: A Case Series from the PPMI Study
Objective: To describe the characteristics of patients initially diagnosed with idiopathic Parkinson’s Disease (PD) and with abnormal dopamine transporter (DAT) imaging who have a change…Pupillary autonomic dysfunction and oculomotor characteristics of multiple system atrophy
Objective: To investigate the pupillary autonomic function and oculomotor characteristics of patients with multiple system atrophy (MSA). Background: MSA is a debilitating neurodegenerative disorder with…Motor and cognitive deficits in a mouse model of tauopathy with tau isoforms imbalance: Potential therapeutic strategies
Objective: This work investigates motor phenotypes and neurochemical changes in a mouse model of tauopathy linked to tau mis-splicing. We sought to validate a potential…Diffusion magnetic resonance imaging for predicting the severity of Progressive supranuclear palsy
Objective: The current study proposed to build a prediction model of clinical severity from the combination of multiple diffusion tensor derived indices in patients with…Olfactory testing in Parkinson plus syndromes
Objective: To determine the diagnostic utility of olfactory testing in patients with neurodegenerative Parkinsonism. Background: Olfactory dysfunction can be identified in the vast majority of…Progressive Supranuclear Palsy and Eye of the Tiger Sign
Objective: To report a typical progressive supranuclear palsy case with "eye of the tiger sign" on MRI Background: Progressive supranuclear palsy (PSP); is a degenerative…PROMESA: A randomised, double-blind, placebo-controlled trial to evaluate the progression rate of MSA under EGCG supplementation as anti-aggregation-approach
Objective: To evaluate the safety and tolerability of epigallocatechin gallate (EGCG) in high doses and its efficacy to slow down disease progression in patients with…