Objective: This study aims to systematically assess the current landscape and evolving trends of research on orthostatic hypotension in the context of age-related neurodegenerative diseases through bibliometric analysis.

Background: Neurodegenerative diseases, as one of the age-related diseases with a high incidence, pose increasing societal and healthcare challenges. Orthostatic hypotension frequently manifests in these conditions, yet its diagnosis and prognostic significance remain poorly understood in neurology. While numerous studies have probed the potential association between orthostatic hypotension and neurodegeneration, the causal nexus remains elusive.

Method: A comprehensive search of the Web of Science Core Collection database was conducted to identify relevant studies focusing on orthostatic hypotension in age-related neurodegenerative diseases.Bibliometric and visual analysis tools were used to explore research trends and key themes.

Results: A total of 887 publications were included in the analysis. The annual publication count exhibited a steady increase from 2004 to 2023, averaging 52 articles per year with a mean citation rate of 5 per year. Publications peaked in 2020 with 106 articles. The highest citation counts were observed between 2018 and 2021, exceeding 3,500 citations annually. The United States, Italy, and China emerged as the leading research nations, contributing 27.96%, 8.91%, and 8.00% of the total publications, respectively. Austria demonstrated the highest level of international collaboration (MCP ratio: 0.517) despite ranking 8th in terms of publication volume.Parkinsonism and Related Disorders emerged as the most prolific journal, while Movement Disorders garnered the most citations. Keywords, ranked by burst strength, were led by “Parkinson’s disease” (strength 6.10), followed by “impulse control disorder” (5.17) and “sleep behavior disorder” (5.07). Current research trends suggest a growing interest in the interplay between Parkinson’s disease, orthostatic hypotension, and associated factors such as impairment, disease progression, and survival.

Conclusion: This bibliometric analysis provides valuable insights into the evolving research landscape of orthostatic hypotension in age-related neurodegenerative diseases. It highlights key areas of investigation, identifies leading research nations and institutions, and reveals shifting research priorities over time.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/orthostatic-hypotension-in-age-related-neurodegenerative-diseases-a-bibliometric-study-from-2007-to-2023/