Objective: This study assessed the neuroprortective effects of combination of CoQ10 with vitamin E in Chronic Cerebral Hypoperfusion-induced neurodegeration (CCH-ND) model of rat.

Background: Alzheimer’s disease (AD) is the most common type of neurodegenerative diseases and the leading cause of dementia in elderly. Number of people with neurodegenerative diseases, is massively increasing. Currently, there is no prevention, no cure and no drug to slow down the progression of AD. Numerous evidences have revealed the presence of oxidative stress in the beginning and progression of AD. Therefore, the potential of using natural antioxidants for prevention and treatment of AD has attracted considerable attention. Coenzyme Q10 and Vitamin E have been reported as powerful antioxidants and used as protective agents for various illnesses. In spite of significant results in experimental studies, which used single antioxidant in AD models, administration of single antioxidant in AD patients has been failed. Therefore, an efficient strategy would be the use of combination of antioxidants in the treatment of Alzheimer’s disease to provide synergetic effects and enough antioxidant action without need of large and toxic doses of using single antioxidant.

Method: Acclimatization, 27 Sprague Dawley rats weighing 200-250 g were divided into six groups. Group A – sham control, Group B – 2VO, and Group C – 2VO+E (treated daily with Vit E, 100 mg/kg, orally following 2VO) Group D treated with Coenzyme Q10, group E treated with combination of CoQ10 and Vit E and group F treated with coconut oil as vehicle. On the 8th week, all the rats were tested by Morris water maze cognitive test and then euthanized and the hippocampi were isolated. Viable neuronal cell count in the hippocampal region was estimated. The Isoprostane F2 (F2-IsoPs) levels were deliberated in the brain homogenates to quantify the oxidative stress status.

Results: There was significant difference in neuronal cell death in 2VO group in comparison to the sham group. There was no statistically significant difference in neuroprotective effects of combination of vitamin E with CoQ10 and each one alone in chronic cerebral hypoperfusion-induced neurodegeneration in rat.

Conclusion: It is advisable that to use a combination of both vitamin E and CoQ10 for better protection against neurodegenerative disorders specially AD and PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuroprotective-effects-of-combined-administration-of-coenzyme-q10-and-vitamin-e-in-chronic-cerebral-hypoperfusion-induced-neurodegeneration-in-rats/