Objective: The aim of the present study was to explore the protective effect of alpha-mangostin against mitochondrial oxidative stress in MPTP treated mice.

Background: It has been reported that mitochondrial oxidative stress plays a pivotal role in neurodegenerative disease like Parkinson’s disease (PD). Recently, medicinal plant extracts acted as traditional, complementary and potential medicine for PD. Alpha-mangostin (AM) is the main xanthone purified from mangosteen known as anti-oxidative properties.

Methods: MPTP was administered repeatedly on 1st, 7th and 14th day intranigrally for the induction of PD in mice. AM (3 and 6mg/kg) and Selegiline (10 mg/kg) were given intraperitonially, after induction of PD for 14 days. Different behavioral performances were carried on 1st, 14th, 21st, 28th  days and biochemical parameters were estimated on 28th day.

Results: Central administration of MPTP showed significant impairment of motor behavior and marked increase of mitochondria oxidative damage and neuro-inflammation in mice. However, post treatment with AM (3 and 6mg/kg) significantly and dose dependently  improved the motor deficits and attenuated the oxidative damage indicating decreased rise of LPO and nitrite concentration and restored the decreased activities of endogenous antioxidant enzyme (Glutathione, Catalase, SOD) and mitochondria enzymes (NADPH dehydrogenase, Succinic dehydrogenase and cytochrome oxidase) as compared to selegiline effects. In addition AM also attenuates the pro-inflammatory cytokines like TNF-α and IL-β in striatum region of MPTP induced PD in mice.

Conclusions: These results suggested that AM exhibit Neuroprotective effect by mediating brain antioxidant defense mechanism and by up regulating of dopaminergic pathway

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MDS Abstracts - https://www.mdsabstracts.org/abstract/neuroprotective-effect-of-%ce%b1-mangostin-in-restoration-mitochondrial-function-in-mptp-induced-parkinsons-disease-in-mice/