Objective: To compare the features of urinary dysfunction in Progressive supranuclear palsy (PSP) with those of idiopathic Parkinson’s disease (IPD) and multiple system atrophy (MSA).

Background: PSP can manifest urinary symptoms, like IPD and MSA do. However, urinary symptoms and its corresponding bladder dysfunctions in PSP have not been well studied to date. 

Methods: We conducted a retrospective analysis of urodynamic data in patients diagnosed of parkinsonian disorders (PSP, IPD, and MSA) and presented urinary symptoms. Clinical information including demographic factors, onset age, duration, severity, treatment of parkinsonism and urinary symptoms in each patients were collected. 

Results: A total of 131 patients (10 with PSP, 79 with IPD, and 42 with MSA) were included. The mean age and the age of disease onset of PSP patients were similar to those of IPD patients, and older than those of MSA patients. The duration of disease until the onset of urinary symptoms in PSP patients was similar to that of MSA patients, and shorter than that of IPD patients. In the urodynamic study, storage phase dysfunctions in patients with PSP were similar to those in patients with IPD or MSA. However, PSP patients showed the higher rates of voiding failure than IPD patients during a pressure-flow study and indicated the lower maximum flow rate, higher post-void residual volume, and higher proportions of impaired detrusor contraction than IPD patients, but rather similar to MSA patients. 

Conclusions: Patients with PSP have variable urinary dysfunctions as much as those with MSA do and have more severe voiding phase dysfunctions than those with IPD. This may reflect the extensive degenerative process of neural structure in patients with PSP.

« Back to 2017 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/neurogenic-bladder-in-progressive-supranuclear-palsy-a-comparison-with-parkinsons-disease-and-multiple-system-atrophy/