Objective: To evaluate the prevalence, interrelation and impact on health related quality of life (HRQL) and Activities of daily Living (ADL) of motor (MS) and non-motor symptoms (NMS) in a sample of Parkinson’s disease (PD) patients.

Background: Some studies have suggested specific relations between MS and NMS. Most studies have focused only on some of these symptoms, creating a need for investigation that includes the complete spectrum of NMS, for a better understanding of their shared physiopathology. NMS have been reported to contribute to the incapacity and influence HRQL, but it is still unclear what the relative weight of each symptom is. Also, the prevalence and impact of each symptom in a specific PD population could vary across different geographic regions.

Methods: We included all PD patients attending a tertiary movement disorders center during one year. They were assessed regarding ADL, HRQL, MS, Cognitive Dysfunction, Depression, Anxiety, Psychosis, Apathy, REM Sleep Behavior Disorder (RBD), Fatigue, Insomnia, Sleepiness, Olfaction, Weight Change, Hyperhidrosis, Gastrointestinal, Cardiovascular, Urinary and Sexual function symptoms. We calculated the prevalence of each non-motor symptom. The relation between symptoms was assessed with principal component analysis and the influence on HRQL and ADL was evaluated with multi-linear regression analysis.

Results: All 134 patients had at least one NMS. Sleep/fatigue, affect/cognition, attention/memory and urinary were the most frequent complaints. The following symptoms were significantly correlated: bradykinesia, rigidity and gait dysfunction; sleepiness, psychosis and attention/memory; gastrointestinal, cardiovascular symptoms and pain; depression and apathy; anxiety and nighttime sleep complaints; olfaction, weight, hyperhidrosis; MoCA score, urinary and sexual dysfunction symptoms; RBD score and Tremor. Depression/apathy exerted the strongest influence on HRQL and non-tremor motor dysfunction on ADL.

Conclusions: Our results show a high prevalence of NMS, with insomnia, affective and urinary symptoms as the most frequent. The interrelation between symptoms shows an intricate pattern, in probable relation with the progressive neurodegeneration of different structures. Our investigation suggests that NMS exert a stronger influence than MS in HRQL, which should be taken in account regarding treatment options.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/motor-and-non-motor-symptoms-in-parkinsons-disease-correlation-and-impact-on-quality-of-life-and-activities-of-daily-living/