Objective: We aimed to analyze the mortality of advanced PD patients who received DBS surgery.

Background: Survival of PD patients has been investigated. Many researchers reported that the mortality rate of PD patients is higher than that of general population. Population-based long-term study reported that age at onset, chronological age, motor severity, dementia, and psychotic symptoms independently predict increased mortality in PD. Despite the widespread use of deep brain stimulation (DBS) for patients with Parkinson’s disease (PD), long-term outcomes are still required to be investigated.

Methods: We assessed the survival rate of consecutive 160 advanced PD patients who underwent DBS surgery between April 2002 and May 2014. Kaplan-Meier survival curves were constructed using death as the endpoint. Cox proportional hazards regression models were used to assess the association of clinical risk factors with survival.

Results: Twenty-seven (16.9%) PD patients (13 men and 14 women) had died by May 10, 2015 in the mean follow-up period of 4.9 ± 3.1 years after DBS surgery. The survival rate was 97% at three years after DBS surgery and 85% at five years after DBS surgery. Pneumonia (N = 7) was the most common specific cause of death. In a step-wise Cox regression analysis, male gender (hazard ratio (HR) = 3.00; 95% confidence interval (CI) = 1.35 – 6.65; P = 0.007), hallucination (HR = 3.95; 95% CI = 1.60 – 9.78; P = 0.003), and the placement of nursing home (HR = 2.81; 95% CI = 1.30 – 6.09; P = 0.009) predicted poor survival.

Conclusions: Our results suggest that poor survival of advanced PD patients who underwent DBS surgery was related to male gender, hallucination, and the placement of nursing home. Further studies with long-term follow-up will confirm these clinical factors influencing mortality of these PD patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/mortality-after-deep-brain-stimulation-surgery-for-patients-with-advanced-parkinsons-disease/