MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Minimum MDS-UPDRS part III change needed to convert a Parkinson’s disease patient from the OFF to full ON state with apomorphine sublingual film (APL-130277)

H. Shill, A. Agro, E.J. Pappert, B. Dzyngel, T. Bilbault, S. Isaacson, R. Hauser (Phoenix, AZ, USA)

Meeting: 2016 International Congress

Abstract Number: 851

Keywords: Apomorphine, Parkinsonism

Session Information

Date: Tuesday, June 21, 2016

Session Title: Parkinson's disease: Pathophysiology

Session Time: 12:30pm-2:00pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: Determine the minimum MDS-UPDRS Part III improvement needed to convert a patient from the morning OFF state to a full ON with APL-130277.

Background: APL-130277 is a sublingual film being studied in Phase 3 trials to rapidly turn patients ON from OFF episodes by delivering apomorphine via the oral mucosa.

Methods: PD patients with at least one OFF episode/day, = or > 2 hours of daily OFF and experienced a predictable OFF episode each morning upon awakening prior to receiving morning dose of levodopa were included. Patients were dosed in the morning OFF state, starting with APL-130277 10 mg and increased in 5 mg increments until a full ON was achieved, to a maximum of 30 mg. MDS-UPDRS Part III and ON/OFF status was determined pre-dose and 15, 30, 45, 60 and 90 minutes after dosing.

Results: Of the 19 patients dosed, 15 converted from OFF to full ON with APL-130277. For the patients who responded within 15 minutes, the mean change in the MDS-UPDRS Part III at 15 minutes post-dose was -12.3 points and the mean % change was -33%. For the patients who responded at a time > 15 minutes but within 30 minutes, the mean change in the MDS-UPDRS Part III 15 minutes post-dose was -11.7 points and the mean % change was -28%. For those 4 patients who did not respond, the mean change on the MDS-UPDRS Part III 15 minutes post-dose was -10 and the mean % change was -19%

Table 1: Mean Change and Mean % Change on MDS-UPDRS-Part III at 15 Minutes
Groups MDS-UPDRS Part III Mean Change from Baseline at 15 Minutes MDS-UPDRS Part III Mean % Change from Baseline at 15 Minutes
Responders within 15 minutes (N=6) -12.3 -33%
Responders > 15 minutes but within 30 minutes (N=9) -11.7 -28%
Non-Responders (N=4) -10 -19%
.

Conclusions: A MDS-UPDRS Part III improvement of over 10 points and a change of at least 20 % at 15 minutes post-dose was needed to turn a PD patient from the morning OFF state to a full ON state. Phase 3 studies are ongoing to further evaluate efficacy and safety of APL-130277.

Presented, in part, at the XXI World Congress on Parkinson’s disease and Related Disorders (December 6-9, 2015; Milan, Italy). P 2.090 Minimum MDS-UPDRS part III change needed to convert a Parkinson’s disease patient from the OFF to full ON state with sublingual apomorphine (APL-130277) J. Dubow, B. Dzyngel, T. Bilbault, A. Giovinazzo, A. Agro (Canada).

To cite this abstract in AMA style:

H. Shill, A. Agro, E.J. Pappert, B. Dzyngel, T. Bilbault, S. Isaacson, R. Hauser. Minimum MDS-UPDRS part III change needed to convert a Parkinson’s disease patient from the OFF to full ON state with apomorphine sublingual film (APL-130277) [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/minimum-mds-updrs-part-iii-change-needed-to-convert-a-parkinsons-disease-patient-from-the-off-to-full-on-state-with-apomorphine-sublingual-film-apl-130277/. Accessed May 13, 2025.
  • Tweet
  • Email
  • Print

« Back to 2016 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/minimum-mds-updrs-part-iii-change-needed-to-convert-a-parkinsons-disease-patient-from-the-off-to-full-on-state-with-apomorphine-sublingual-film-apl-130277/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • An Apparent Cluster of Parkinson's Disease (PD) in a Golf Community
  • The hardest symptoms that bother patients with Parkinson's disease
  • Life expectancy with and without Parkinson’s disease in the general population
  • Patients with Essential Tremor Live Longer than their Relatives
  • #23624 (not found)
  • The hardest symptoms that bother patients with Parkinson's disease
  • Three cases of early tremor in the course of Guillain-Barré Syndrome
  • The impact of gastric acid suppressants and antacids on levodopa plasma concentration in patients with Parkinson’s disease
  • To be or not to bupropion: a drug-induced parkinsonism?
  • The Role of MRI and DaTscan in Vascular Parkinsonism: A Case Report
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley