Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: To characterize the handicap of a broad sample of PD patients.
Background: Measuring perceived-health status has an important role in Parkinson’s Disease (PD) to monitor its impact on daily living. Handicap is a patient-centered outcome measure of health status that encompasses the impact of social and physical environment on daily living. It was previously assessed in advanced and late-stage PD patients, but there is no data concerning the rest of the disease spectrum.
Method: 405 PD patients were assessed during the MDS-UPDRS Portuguese validation study, using the MDS-UPDRS, Unified Dyskinesias Rating Scale, Nonmotor symptoms questionnaire and PDQ-8, in a cross-sectional study. Handicap was measured using the London Handicap Scale (LHS) (maximum handicap=0; minimum handicap=1). Spearman’s rank correlation and multiple linear regression were used to determine handicap predictors.
Results: Mean age 64,42 (±10,3) years, mean disease duration 11,30 (±6,5) years and median Hoehn and Yahr (HY) 2 (IQR, 2-3). Mean LHS total score was 0,652 (±0,204). Mobility, Occupation and Physical Independence were the most affected subdomains. Handicap was significantly correlated with disease duration (r=-0,35), motor experiences of daily living (EDL) (MDS-UPDRS-II) (r=-0,69), nonmotor EDL (MDS-UPDRS-I) (r=-0,51), motor disability (MDS-UPDRS-III) (r=-0,49), axial signs of MDS-UPDRS-III (r=-0,55), HY stage (r=-0,44), presence of nonmotor symptoms (r=-0,51) and PDQ-8 index (r=-0,64)(all p<0.05). Motor EDL, MDS-UPDRS-III and PDQ-8 independently predicted Handicap (adjusted R2 = 0,582; p=0,007).
Conclusion: The LHS was easily completed by patients and caregivers, independently of disease duration. Patients were mild to moderately handicapped, which increased significantly with disease duration. Motor disability and its impact on EDL and poor QoL strongly determined handicap. Despite strongly correlated, handicap and QoL might measure different perceived-health status. Handicap seems to be a good measure of perceived-health status in PD.
To cite this abstract in AMA style:
D. Silva, M. Coelho, T. Soares, T. Vale, L. Guedes, R. Maciel, A. Antunes, S. Camargos, A. Valadas, C. Godinho, D. Maia, P. Lobo, R. Maia, T. Teodoro, C. Rieder, A. Velon, M. Rosas, A. Calado, V. Caniça, F. Cardoso, J. Ferreira. Measuring perceived-health status in Parkinson’s Disease – the role of London Handicap Scale [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/measuring-perceived-health-status-in-parkinsons-disease-the-role-of-london-handicap-scale/. Accessed May 9, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/measuring-perceived-health-status-in-parkinsons-disease-the-role-of-london-handicap-scale/