Objective: To examine the association between incident Parkinson’s disease (PD) and metabolic syndrome (MetS)  in a retrospective population study for an extensive period before diagnosis.

Background: Identifying risk factors is of great importance for understanding the pathogenesis of PD, promoting pre-symptomatic treatment, and changing behavior or lifestyle to prevent or slow disease progression.

Method: Longitudinal data was obtained from electronic health records. The final cohort (after exclusion criteria) included 890 PD patients and 8,100 controls with demographic data, blood test results, BMI measurements, diagnoses, and pharmacological treatment up to fifteen years before the diagnosis date (DoD). We examined the relationship between metabolic biomarkers and disease incidence by comparing the levels of these markers, stratifying by age and sex, analyzing the pharmacological impact, and calculating the Odds ratio (OR) for PD incidents over the years before DoD.

Results: Metabolic syndrome was significantly associated with a lower incidence of PD for fifteen years before DoD (annual ORs of 0.57-0.8). PD patients had significantly lower triglyceride levels for fifteen years before DoD with significant ORs in the last six years of 0.44-0.75, The differences are more evident in males. Female PD patients had significantly lower High-density lipoprotein (HDL) levels with significant ORs of 1.48-1.82 in the last five years before DoD, and higher Low-density lipoprotein (LDL)/ HDL ratio compared to that of female controls with significant ORs of 0.46-0.64 in the last eight years. The prevalence of PD patients who purchased medications for hypertension was lower than controls for the entire period, more evident in females. We saw a decrease in BMI levels of female PD patients eleven years before DoD, the difference is significant for the last four years.

Hyperglycemia had an inverse association with future incidence of PD yet was significant for only the last three years with ORs of 0.81-0.86. In accordance, hemoglobin A1C levels and diabetes medication consumption demonstrated an inverse association with PD, more eminent in females.

Conclusion: Metabolic syndrome and all its components are associated with a lower future incidence of PD for extensive periods before DoD. Furthermore, sex has a substantial impact on the association with PD.

« Back to 2024 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/lower-incidence-of-parkinsons-disease-in-patients-with-metabolic-syndrome-or-any-of-its-components-a-longitudinal-study/