Objective: To assess the utility of beta-band suppression as a tool for contact selection in patients undergoing nucleus subthalamicus (STN) deep brain stimulation (DBS) for Parkinson’s Disease (PD).

Background: Suppression of pathologically altered activity in the beta-band has been previously suggested as a biomarker for feedback-based neurostimulation in STN-DBS for PD. However, apart from adaptive stimulation algorithms, programming of stimulation parameters remains one of the most challenging factors in postoperative management of these patients.

Method: A sample of seven PD patients (13 hemispheres) with newly implanted directional DBS leads of the STN were recorded during a standardized monopolar contact review (MPR). Recordings were received from contact pairs adjacent to the stimulation contact. The degree of beta-band suppression for each investigated contact was then correlated to the respective clinical results.

Results: Stimulation ramping led to frequency-specific changes in the beta-band, while lower frequencies remained unaffected. Most importantly, our results showed that the degree of low beta-band suppression from baseline activity (stimulation off) served as a predictor for clinical efficacy of the respective stimulation contact. In contrast suppression of high beta-band activity yielded no predictive power.

Conclusion: The degree of low beta-band suppression can serve as a tool for contact selection in STN-DBS and benefits from additional objective control.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/low-beta-band-suppression-as-a-tool-for-dbs-contact-selection-for-akinetic-rigid-symptoms-in-parkinsons-disease/