Objective: To assess the evolution of lung volumes and respiratory muscle strength after a 5 years follow-up in a cohort of patients with Parkinson’s disease (PD) and to determine the prognostic factor of the ventilatory disorder in the disease.

Background: Pulmonary dysfunction is related among axial and non-motor symptoms of PD. It impacts the quality of life and could affect the prognosis. However, most of the studies assessed it in advanced PD patients without any prospective follow-up.

Method: Twenty-seven early-stage PD patients (mean age at inclusion (V0) = 67.3 ± 7.6) with a mean disease duration at V0 of 1.9 years (± 1.6) were included and followed up during 5 years. Neurological examination and pulmonary function tests were performed at V0, repeated 2 years (V2) and 5 years later (V5).

Results: At V5, vital capacity (VC, p=0.001), forced expiratory volume in 1 second (FEV1, p=0.007), functional residual capacity (FRC, p=0.0003), total lung capacity (TLC, p=0.0008) and the sniff nasal inspiratory pressure (SNIP, p=0.002) significantly decreased. Conversely, the FEV1/VC ratio, the maximal inspiratory and expiratory mouth pressures (MIP and MEP) and peak expiratory flow were not different. Neither VC at V0, nor early inspiratory muscles weakness was associated with a worse motor and non-motor outcome at V5.

Conclusion: We demonstrated for the first time that the lung volumes decreased after 5 years of progression in PD. We need to confirm the results in a larger sample in order to determine the prognostic value of this global ventilatory disorder.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/long-term-evolution-of-ventilatory-function-in-parkinsons-disease/