Objective: To evaluate the power spectrum of LFPs in motor subtypes of Indian PD patients.

Background: Though the motor subtypes of the Parkinson’s disease (PD) is such as tremor or rigidity dominant have been defined based on symptoms, no underlying neural correlates of these clinical subtypes have not yet been identified. Very limited data exist regarding the electrophysiological abnormalities within the subthalamic nucleus (STN) that likely accompany the symptom severity or the phenotype of PD.

Method: 16 patients diagnosed with PD, who were eligible for bilateral STN DBS as per CAPSIT-PD Protocol and are willing to participate were included in the study after obtaining informed consent. UPDRS III scores were obtained. Both MUA and LFP recordings were done using the same microelectrodes by adjusting the appropriate filter settings during the DBS surgery. Recording were obtained and post-operative offline analysis was done for all the 5 channels. Recordings were taken at 1mm intervals, starting 5mm above and ending 5mm below the anatomical target. This was done bilaterally for all the patients and results were analyzed using appropriate statistical methods to correlate with the motor subtypes in the patients.

Results: The mean disease duration was 6.23±4.16 years and the average UPDRS III off score was 49±6.  The frequency of spectral power density peaks varied among subjects. The lower frequency peaks were less prominent and a more prominent peak in the beta range was observed which varied intra as well as interpersonally from 13 – 27 Hz . Mean frequency was 20 ± 4.03  and mean power was 0.678
No statistical difference was seen between the two groups.

Conclusion: Beta oscillations (beta power) in the STN can be used as a biomarker for closed-loop DBS in PD patients. A well designed clinical approach leading to an individually tailored treatment, may at least offer a partial relief for patients suffering from tremors.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/lfp-in-motor-subtypes-of-parkinsons-disease/