Objective: The aim of this study investigation of the effects of gene expressions before and after propranolol treatment.

Background: Essential tremor (ET) is the most common disease among movement disorders. It’s prevalence increseases with age. About 50% of ET patients have affected members in their families. Until today genetic researches on ET have described more than one different gene loci responsible for the disease. In the population studies ETM1-4, HS1BP3, DRD3, LING01, SLC1A2, FUS, HTRA2 and TENM4 genes have been shown to on responsible in the disease’s genetic patterns.

Method: This prospective study was formed by the two  groups.  The patient group was collected 38 ET patients and second group was collected 20 healthy control.  Then, DRD3, SCL1A2 and HTRA2 gene expressions were evaluated before treatment among the groups. Finally, these genes expressions were evaluated again among the ET patient group two months after the propranolol treatment.

Results: We found that gene expression of the DRD3 and SLCA2 was lower than control group. But, HTRA2 gene expression value was higher compared to control. In the patient group DRD3 gene expression value was determined as 1.2 ± 1.6. This ratio was found 5.3±4.7 in the control group. The DRD3 gene expression was found as 0.7±0.6 after the propranolol treatment. SLC1A2 gene expression value was determined as 2.3±3. In the control group the value found 10.6±8.2. The value of SLC1A2 gene expression determined  0.4±4 after propranolol treatment. HTRA2 gene expression in patient group (6.2±7.5) was found higher compared to control group (1.8±0.98). This rise determined to be partially decrease (4.3±6) after the period of propranolol treatment.

Conclusion: Our results indicates that  the same similarity to the repressive character of propranolol over the protein synthesis and gene expression in prior studies. The therapeutic effects of propranolol in the patients with ET can be explained by its impessive effects on the brain functions together with its repressive effects on the protein synthesis and gene expression.

References: 1- S.-W. Yu, C.-M. Chen, Y.-C. Chen et al., “SLC1A2 variant is associated with essential tremor in taiwanese population,” PLoS ONE, vol. 8, no. 8, article e71919, 2013. 2- H. U. Gulsuner, S.Gulsuner, F. N. Mercan et al., “Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no.51, pp. 18285–18290, 2014. 3- Thier S. Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor. Neurology 2012; 79: 243–8.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/investigation-of-the-effects-of-propranolol-on-drd3-slc1a2-and-htra2-gene-expression-in-patients-with-essential-tremor/