Objective: To identify changes in anti and pro-inflammatory cytokines and cortisol hormone levels in patients with Parkinson’s disease undergoing dance therapy.

Background: Parkinson’s disease(PD) pathophysiology involves inflammatory and immune responses that can be associated with the severity and progression of the symptoms.The protective and neuroplastic effects of exercise have been shown to involve anti-inflammatory signals that seem to be associated with alleviation of some of the clinical characteristics of PD.Dance-based exercise have been increasingly used as motor therapy with reasonable outcomes for PD patient’s.

Method: Volunteers with idiopathic PD and healthy volunteers were included in one of the groups:PD group(“PD”; n=8),PD group undergoing dance therapy(“PD+dance”; n=9),or age and gender-matched healthy subjects(“control”; n=8).The mean ages of the groups were 63,22 ± 9,40(PD+Dance); 67,25 ± 13,4(PD) and 59,12 ± 10,73(control).Time since diagnosis varied between 4,55 ± 2,50 years for PD+Dance group and 7,22 ± 5,80 years for PD group.Groups didn´t differ in terms of age and time since diagnosis(p>o,o5), and PD groups were both in Hoehn &Yahr stages I-III.All volunteers underwent a clinical evaluation and had 10ml of peripheral blood collected for analysis.Serum levels of IL-4 and IL-1α cytokines and cortisol hormone were evaluated by enzyme-linked immunosorbent assay. ANOVA one-way was used to analyze the parametric data and Kruskal-Wallis post-test for nonparametric data(p<0.05).

Results: The serum levels of IL-4 were significantly reduced in PD group when compared to the control group(PD+dance: 0,2300 ± 0,08; PD: 0,1280 ± 0,02; control: 0,37 ± 0,05; p=0,0066). We observed no significant differences in the serum levels of IL-1α(PD+dance: 0.01 ± 0.01; PD:0,022 ± 0,02; control: 0,008± 0,004) and cortisol hormone(PD+dance: 10,32 ± 2,75;PD:11,57 ± 5,31; control:12,40 ± 3,86) between the analyzed groups.

Conclusion: Studies have investigated the importance of IL-4 as a potent regulator of inflammation, with the ability to regulate the activation of microglia.Patients included in the dance therapy had levels of IL-4 concentration similar to the individuals of the control group whereas such levels were reduced in people with Parkinson’s Disease in this essay.The effects of dance practice seemed to restore such levels close to the ones observed on age-matched healthy subjects.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/interleukin-4-il-4interleukin-1%ce%b1-il-1%ce%b1-and-cortisol-serum-levels-in-parkinsons-disease-patients-undergoing-dance-therapy/