Session Information
Date: Wednesday, June 7, 2017
Session Title: Parkinson's Disease: Psychiatric Manifestations
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: Investigate the prevalence and characteristics of Impulse Control Disorders (ICDs) in the PD population as compared to non-ICD patients in the Rush University Movement Disorders (RUMD) database.
Background: Up to 30% of patients chronically on dopamine agonists (DA) will develop ICDs. The prevalence, risk factors, and demographics of the PD patients with ICDs at RUMD has not been studied.
Methods: Retrospective chart analysis of features of all patients diagnosed with an ICD in the database over the past five years (n=27), from a total of 2823 patients. Case-control design was utilized; matched for age (+/5 years) and gender.
Linear model was used for analysis of the continuous variables and Mantel-Haenszel chi-square for other variables to compare the key descriptors.
Results: For cases, average age at ICD diagnosis was 63.11 (SD 7.7), 74% were male, with an average disease duration of 8.68 (SD 6.5) years. For controls, same baseline demographics. 31% had multiple ICDs and the two most common ICDs were hypersexuality (30%) and gambling (30%). There was a significantly higher prevalence in ICD subjects of depression (p=.012), hallucination (p=.02), REM-behavioral sleep disorder (p=.01), and insomnia (p=.0005). Consistent with previous studies, levodopa dose (case =757.4 (+ 528); control 500.9 (+ 345.9) (p=0.01)) and pramipexole dose (case 0.88 (+ 1.5); control 0.20 (+ 0.7) (p=0.007)) were significantly higher in the ICD population. We did not find a difference in UPDRS Part III or HY score, presence of dyskinesia, or prevalence of anxiety or cognitive impairment.
Conclusions: Our findings suggest that ICD patients have more insomnia, RBD and hallucinations than non-ICD PD patients. The ICD prevalence was lower than has been reported, suggesting that it is grossly under-reported and under-screened in our large PD population. This information allows us to better identify risk factors and screening methods in future ICD patients.
To cite this abstract in AMA style:
M. Rossi, G. Stebbins, B. Barton. Impulse Control Disorders in Parkinson’s Disease: Prevalence and Clinical Features in the Rush University Movement Disorders Clinic [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/impulse-control-disorders-in-parkinsons-disease-prevalence-and-clinical-features-in-the-rush-university-movement-disorders-clinic/. Accessed May 14, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/impulse-control-disorders-in-parkinsons-disease-prevalence-and-clinical-features-in-the-rush-university-movement-disorders-clinic/