Impulse control disorder in Parkinson's disease is not related to lower cognitive performance

J. Marin-Lahoz, R. Fernandez-Bobadilla, J. Pagonabarraga, S. Martinez-Horta, B. Pascual-Sedano, J. Perez-Perez, H. Bejr-Kasem, A. Gironell, J. Kulisevsky (Barcelona, Spain)

Meeting: 2016 International Congress

Abstract Number: 1487

Keywords: Cognitive dysfunction

Session Information

Date: Wednesday, June 22, 2016

Session Title: Parkinson's disease: Psychiatric manifestations

Session Time: 12:00pm-1:30pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: To compare cognitive performance in patients with and without Impulse Control Disorders (ICD) according to MDS recommendations for Parkinson’s disease (PD) Mild Cognitive Impairment (MCI) evaluation.

Background: Some cognitive dysfunctions have been communicated in ICD patients but there are not studies performing comprehensive testing based on level 2 MDS MCI recommendations. Also the differences found may be related to age or disease duration and not due to the presence of ICD.

Methods: We performed comprehensive cognitive testing according to level 2 recommendations for PD MCI for a sample of 17 PD patients with ICD. We recruited 17 PD patients with no ICD frequency matched for sex and age. We compared performance in 2 tests for each 5 cognitive domains using t test.

Results: Both groups had same sex distribution (5 female, 12 male) and similar age (57.6 vs 58.2, p=0.87). Education and disease evolution were also similar (p=0.67 and p= 0.37). Levodopa equivalent daily dose was higher in ICD but did not reach statistical significance (p=0.07).

General comparison
	ICD-	ICD+	Significance (p)*
Age	58.2	57.6	0.87
Sex(male)	12/17	12/17	1
Disease duration(years)	1.9	2.6	0.36
LEDD	312	462	0.07
Education(years)	12.4	13.2	0.67

LEDD: levodopa equivalent daily dose. *Significance tests: t test for all except sex proportion for which chi square was used. Performance was very similar in attention, language, memory and visuospatial domains (p>0.36 in all comparisons). On executive function, Trail Making Test B performance was better in ICD group but the difference did not reach statistical performance (p=0.09). Other measures for executive performance did not differ (action fluencies p=0.45, alternate fluencies 0.51).

Cognitive performance
Domain/Test	ICD-	ICD+	Significance (p)*
Attention and working memory
TMT A	53.9	47.3	0.45
Backward digits	10.4	10.1	0.69
Executive
TMT B	174	102	0.09
Alternating fluences	11.7	12.6	0.51
Lenguage
BNT	54.1	55.4	0.39
Token	34.29	35.1	0.49
Memory
FCSRT	14.5	14.6	0.76
ROCF	16.82	14.88	0.36
Visuospatial
JLOT	21.6	22.9	0.53
VOSP	15.9	15.47	0.48

TMT: trail making test, BNT: Boston naming test, FCSRT: Free and Cued Selective Reminding Test total deferred, ROCF: Rey-Osterrieth Complex Figure deferred, JLOT: Judgment of Line Orientation Test, VOSP: Visual Object and Space Perception Battery (objects), * significance in t test“

Conclusions: Global cognitive performance was similar in patients with and without ICD. While PD ICD patients are known to make impulsive choices both in laboratory settings and in life, this is not related to a decrease in cognitive performance compared to otherwise similar PD patients.

To cite this abstract in AMA style:

J. Marin-Lahoz, R. Fernandez-Bobadilla, J. Pagonabarraga, S. Martinez-Horta, B. Pascual-Sedano, J. Perez-Perez, H. Bejr-Kasem, A. Gironell, J. Kulisevsky. Impulse control disorder in Parkinson’s disease is not related to lower cognitive performance [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/impulse-control-disorder-in-parkinsons-disease-is-not-related-to-lower-cognitive-performance/. Accessed November 24, 2024.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/impulse-control-disorder-in-parkinsons-disease-is-not-related-to-lower-cognitive-performance/