Objective: Our objective was to probe the significant role of lateralization in the pathogenesis of ICD.

Background: Impulse control disorders (ICD) in Parkinson’s disease (PD) might be ascribe to misevaluation of rewards or the failure to curb inappropriate choices. The mechanisms underlying ICD were reported to involve the laterality of monoamine network.

Method: Twenty-one PD patients with ICD (PD-ICD), thirty-three without ICD (PD-no ICD), and thirty-seven healthy controls (HCs) were recruited and performed T1-weighted and resting state functional magnetic resonance imaging (rs-fMRI). By applying the Voxel-mirrored Homotopic Connectivity (VMHC) and Freesurfer, we evaluated these participants’ synchronicity of functional connectivity and structural changes between hemispheres.

Results: PD-ICD group demonstrated reduced VMHC values in middle frontal gyrus (MFG) in relative to PD-no ICD group. Compared to HCs, PD-ICD group mainly showed decreased VMHC values in MFG, middle and superior orbital frontal gyrus (OFG), inferior frontal gyrus (IFG) and caudate, which were related to reward processing and inhibitory control. However, we found no corresponding asymmetrical alteration in cortical thickness. Importantly, the severity of impulsivity evaluated by Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease Rating Scale (QUIP-RS) was negatively correlated with the mean VMHC values of MFG in PD-ICD group. Receiver operating characteristic (ROC) curves analyses uncovered that the mean value of VMHC in the MFG might be act as a marker identifying PD-ICD patients from PD-no ICD patients or HCs.

Conclusion: Our results provided further evidence for asymmetry of functional connectivity in mesolimbic reward and response inhibition network in ICD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/impaired-interhemispheric-synchrony-in-parkinsons-disease-patients-with-impulse-control-disorders/