Objective: to study the impact of culture on the categories of impulse control disorders ( ICD ) in PD and its association with levodopa-induced dyskinesia (LID). ( a correlation between motor and non-motor hyperdopaminergic states)

Background: Impulse control disorders in PD represent the major non-motor complications of dopaminergic treatment and Levodopa-induced dyskinesias constitute the other essential motor complications of the same treatment. Both of them are common and debilitating. They may coexist and an association has been proposed

Method: This cross-sectional study was conducted on 30 patients with Parkinson’s disease attending the movement disorders outpatient clinic at Ain Shams University Hospital, Egypt. Each patient underwent a comprehensive assessment including MDS-UPDRS part III and part IV, Hoehn and Yahr rating (H&Y), Unified Dyskinesia Rating scale(UDysRs), Questionnaire for Impulsive Compulsive Disorders in Parkinson’s Disease Rating Scale(QUIP-Rs), PD NMSS questionnaire, Montreal Cognitive Assessment Arabic version(Arabic MoCA), Beck depression inventory(BDI) and Parkinson’s anxiety scale(PAS).

Results: Out of the 18 patients with impulse control disorders:1 with pathological gambling, 6 with hypersexuality, 1 with compulsive buying, 8 with binge eating, 5 with hobbyism and punding,  and 9 with PD medication overuse. This study didn’t show a significant correlation between LID and ICD in PD patients. Additionally, a fair correlation is demonstrated between the Unified dyskinesia rating scale and scores of levodopa equivalent daily dose (LEED), disease duration, levodopa duration and MDS-UPDRS part 3 while there was no significant correlation between the Unified dyskinesia rating scale and both age and MOCA scale results. Similarly, there is no significant correlation between QUIP-Rs regarding age, LEED, disease duration, levodopa duration, MDS-UPDRS part 3, PD NMSS, BDI and PAS.

Conclusion: 60% of our Parkinson’s disease patients with dyskinesia have impulse control disorders which are clinically significant. However, there was no correlation between the total scores of the Unified Dyskinesia Rating scale and the total scores of the Questionnaire for Impulsive Compulsive Disorders Rating scale. There is a fair correlation between the Unified Dyskinesia Rating scale total score and scores of LEED , disease duration, levodopa duration and MDS-UPDRS part 3.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/impact-of-culture-on-impulse-control-disorders-and-correlation-with-levodopa-induced-dyskinesia-in-parkinsons-disease-in-egypt/