Session Information
Date: Wednesday, September 25, 2019
Session Title: Neuroimaging
Session Time: 1:15pm-2:45pm
Location: Les Muses Terrace, Level 3
Objective: We examined the activity of the glymphatic system in patients with Parkinson’s disease using diffusion tensor image analysis along the perivascular space (DTI-ALPS).
Background: The glymphatic system may be impaired in Parkinson’s disease, leading to disturbed clearance of toxic metabolites.
Method: Twenty consecutive subjects with Parkinson’s disease were evaluated with 3 Tesla diffusion tensor magnetic resonance imaging, and clinical diagnosis was solidified during follow-up. For diffusion tensor imaging, we calculated diffusivities in the x, y, and z axes on the plane of the lateral ventricle along the projection fibers and association fibers, to perform DTI-ALPS. The diffusivity index on DTI-ALPS was compared with the unified Parkinson’s disease rating scale score.
Results: We observed a significant negative correlation between the diffusivity index on DTI-ALPS and the unified Parkinson’s disease rating scale score, which suggests the lower the water diffusion along the perivascular space, the more severe the degree of parkinsonism.
Conclusion: The activity of the glymphatic system on DTI-ALPS showed a relation between water diffusion and parkinsonism. Further studies are needed to establish glymphatic imaging methodology for Parkinson’s disease and parkinson-plus syndromes.
To cite this abstract in AMA style:
JM. Kim, YJ. Bae. Glymphatic system activity in Parkinson’s disease: diffusion tensor image analysis along the perivascular space (DTI‑ALPS) [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/glymphatic-system-activity-in-parkinsons-disease-diffusion-tensor-image-analysis-along-the-perivascular-space-dti%e2%80%91alps/. Accessed September 7, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/glymphatic-system-activity-in-parkinsons-disease-diffusion-tensor-image-analysis-along-the-perivascular-space-dti%e2%80%91alps/