Objective: The focus of this study was to assess the burden of PD in the organization for economic cooperation and development (OECD) region from 1990-2019.

Background: Parkinson’s disease (PD) is, a profound neurodegenerative ailment, has been increasingly recognized worldwide due to its growing occurrence and its significant implications on individual health and healthcare systems.

Method: Leveraging the Global Burden of Disease tool, we evaluated the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of PD by age, gender, and year throughout the 38 OECD between 1990-2019. Results were presented both as absolute counts and age-standardized rates (per 100,000).

Results: The overall PD prevalence rose dramatically from 1.3 million (95%UI:1.1-1.5) in 1990 to 2.7 million (2.4-3) in 2019. Similarly, fatalities grew from 56,510 (52,080-58,657) in 1990 to 131,589 (115,716-140,334) in 2019, and DALYs surged from 966,486 (896,196-1,035,722) in 1990 to 2,014,159 (1,824,390-2,160,382) in 2019. Noteworthy national variations emerged; the republic of Korea (RK) witnessed a 347% spike in annual percentage of change (APC) in incidence, whereas United States (US) experienced a 307% rise from 1990-2019. Highest APC in Deaths observed in RK by 435%. The US bore the most considerable PD burden in 2019. USA reported the highest age-standardized incidence rate (ASIR) at 26.44 cases per 100,000, while Iceland noted the highest mortality rate at 5.79 per 100,000 in 2019. Astonishingly, the 95+ age demographic showcased an incidence surge by 397% from 1990-2019, with the 75-79 age bracket having the highest incidence (84,739) and the 80-84 group recording the most deaths (34,137) in 2019. Gender disparities were evident, with females bearing a more significant PD burden: incidence rates for males vs. females were 205% vs. 83%, deaths were 159% vs. 104%, and DALYs were 131% vs. 82% from 1990-2019.

Conclusion: In 2019, PD was identified as the 19th most common cause of death among all causes in OECD countries. Over the past three decades, the OECD region has experienced a pronounced escalation in the burden of PD. Remarkably, males bore a disproportionately greater brunt than females, and older age groups faced heightened vulnerability. This expanding burden underscores the pressing need for region-specific strategies and interventions to manage and mitigate the impacts of PD in the OECD context.

Global Trend of PD

Sexwise Distribution of PD

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MDS Abstracts - https://www.mdsabstracts.org/abstract/global-trend-of-parkinsons-disease-in-38-oecd-countries-from-1990-2019-an-insight-from-the-gbd-2019/