Session Information
Date: Monday, June 5, 2017
Session Title: Parkinson's Disease: Non-Motor Symptoms
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: Our aim was to identify if there is any difference in the genetic variants linked to an increased susceptibility to suffer impulse control disorders (ICDs) or compulsive behaviors (CBs) in Parkinson’s disease (PD) compared to healthy controls (HC).
Background: ICDs and CBs are non-motor symptoms that frequently appear in PD. The treatment with dopamine agonists are markedly linked to both conditions. Nevertheless, a susceptibility genetic background has been described in PD patients since some variants in dopamine metabolism genes seem to be involved in increasing the risk of develop ICDs and CBs.
Methods: We included 365 PD patients (60% males, 64.8±11.5 years) and 382 HC (50.7% males, 59.5±15.3 years). ICDs and CBs were assessed using QUIP-RS questionnaire. Demographic data were recorded in both groups. Clinical features and dopamine replacement therapy data were collected in PD group. Variants in DRD2 (rs1800497, rs1800496), DRD3 (rs6280), COMT (rs4680), GRIN2B (rs1806201, rs7301328) and HTR2A (rs6313) were analyzed in both groups. The genotyping was carried out using the TaqMan technology. Allelic association study was done using PLINK software.
Results: ICDs and CBs were more frequent in PD compared to HC (p<0.001). Adjusted by age and sex this result remained significant. In HC some variants (rs6280, rs1806201, rs4680 and rs6313) had a tendency to influence in isolated ICDs or CBs. In the PD group, the variant rs6313 in HTR2A was associated to a higher susceptibility to suffer ICDs (p=0.04). Accounting by specific ICDs and CBs, this variant was significantly associated to gambling, hypersexuality, compulsive shopping and hobbysm.
Conclusions: Some variants may influence in ICDs or CBs in PD and HC. The polymorphism rs6313 in HTR2A (serotonin receptor) may act on the serotonin function and have an important impact on ICD and CBs in PD.
To cite this abstract in AMA style:
S. JESUS, C. TEJERA-PARRADO, C. CORTES, M. BONILLA-TORIBIO, I. BERNAL-BERNAL, M. LABRADOR, L. VARGAS-GONZÁLEZ, M. BERNAL, A. ADARMES, F. CARRILLO, M. CARBALLO, P. GÓMEZ-GARRE, P. MIR. Genetic susceptibility associated to impulse control disorders and compulsive behaviors in Parkinson’s disease from a Spanish population. [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/genetic-susceptibility-associated-to-impulse-control-disorders-and-compulsive-behaviors-in-parkinsons-disease-from-a-spanish-population/. Accessed May 15, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/genetic-susceptibility-associated-to-impulse-control-disorders-and-compulsive-behaviors-in-parkinsons-disease-from-a-spanish-population/