Objective: Parkinson’s disease is second most common neurodegenerative t disorder with increasing burden  in under developed countries with poor health facilities. Motor and non motor symptoms are important determinants of health and quality of life among PD patients.

Background: Parkinson’s disease is second most common neurodegenerative movement disorder with increasing burden by aging population in under developed countries with poor health facilities. Motor and non motor symptoms are important determinants of health and quality of life among PD patients.

Method: This one and half year study was conducted in a local neurological unit to quantify the gender difference of motor and non motor symptoms among Parkinson’s patient. To address the problems Non Motor Symptoms Scale (NMSS) was used and validated in PD Patients.

Results: Among 231 patients 184 were male and 47 were female. The response rate was (76.8%). With 37(16 % patient) having positive family history. There was demographic difference with more patient (60%) belonging to rural area with only 8% belonging to tribal areas. Most number of people were affected between the age group of 51-60 years. With least number of people over the age of 80 years. Youngest case of PD was observed at the age of 21 years. Although, there was no significant gender difference for motor symptoms but male have more severity for non motor symptoms. Males were more affected with tremors than females. Our data revealed that among Classical clinical features of  Parkinson bradykinesia was in 131 male and 37 female, rest tremor 98 male 35 female, rigidity 171 male 47 female, gait disturbance 139 male 37 female. >40 male. Common non motor symptoms among our PD patients are mood/ cognition, hallucinations, attention/ memory loss. Men reported more sleep disorders, autonomic dysfunction, gastrointestinal symptoms, and sexual dysfunction and speech problems. Neuropsychiatric symptoms are present among 85 (67%).

Conclusion: This study shows that motor and non motor symptoms severity varies among male and female with male affected more. Rural residence has strong impact on the occurrence of PD. .

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MDS Abstracts - https://www.mdsabstracts.org/abstract/gender-differences-for-motor-and-non-motor-symptoms-in-parkinsons-disease-among-pakistani-population/