Objective: Our objective was study the metabolism of brain in a group of patients with Tourette´s Syndrome.

Background: The pathophysiology and anatomical basis of Tourette syndrome are not well known, some studies are suggesting the participation of corticoestriatal circuits.

Methods: We included 4 patients, with Tourette syndrome (DSM-V), as well as 10 healthy subjects. Neuropsychological, neuropsychiatric and PET-FDG was done. The neuropsysochological battery was the tests included in the Neuronorma standardization project. The neuropsychiatric screening tests were Hamilton scale for anxiety, Beck scale for depression, questionnaire for screening of Adult ADHD and Yale-Brown obsessive compulsive scale. The motor symptoms were evaluated with the Yale Global Tic Severity Scale. Brain metabolism was analyzed by Morphometry based on voxels using Statistical Parametric Mapping 8 program.

Results: 4 patients with a median age of 36 years (24-66), 3 of them males, with a median age of onset of symptoms 7 (6-8) years. Total medium score of Yale Global Tic Severity Scale was 33. Anyone have psychiatric disorders. There were signs of Executive dysfunction in 3 patients. Hipometabolism was observed in bilateral frontomedial y recto gyrus (11 and 15 of Brodmann areas) in all patients with syndrome GT compared with healthy controls.

Conclusions: Executive dysfunction and an orbitofrontal hipometabolism were observed. These results suggest the involvement of prefrontal and orbitofrontal cortex in the pathophysiology of Tourette’s syndrome.

SEN, Barcelona, 2014.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/frontal-dysfunction-in-tourette-syndrome-a-pet-fdg-study/