Objective: The aim of this study is to explore the potential effect of reproductive factors on the clinical features of Parkinson’s disease (PD) from a large cohort of Chinese population

Background: Estrogen not only plays a key role in the risk of developing PD but also influences the severity of the disease. 

Methods: A cross-sectional analysis on 264 female Chinese patients with PD was conducted. The motor symptoms, non-motor symptoms and quality of life of patients with PD were measured with different assessment scales. The reproductive factors including age at menarche, age at final menstrual period and reproductive lifespan were recorded.

Results: Of 264 patients, 68 PD patients (25.75%) reported that the onset of PD were before menopause. Correlative analysis indicated that age at menarche was positively associated with Unified PD Rating Scale (UPDRS) part III (r＝0.200, p＝0.811), Montreal Cognitive Assessment (MoCA) (r＝-0.174, p＝0.029), Hamilton Depression Rating Scale (HAMD) (r＝0.192, p＝0.019), Hamilton Anxiety Rating Scale (HAMA) (r＝0.199, p＝0.282) and Beck Depression Inventory（BDI）(r＝0.282, p＝0.001) scores, and age at menopause was correlated with PD Questionnaire 39（PDQ-39）scores (r＝-0.168, p＝0.036). Similarly, reproductive lifespan was positively associated with UPDRS Ⅲ (r＝-0.198, p＝0.013), MoCA (r＝0.165, p＝0.038), PDQ-39 (r＝-0.231, p＝0.004), Non-Motor Symptoms Scale (NMSS)(r＝-0.232, p＝0.004), HAMD (r＝-0.173, p＝0.035), HAMA (r＝-0.215, p＝0.009) and BDI (r＝-0.274, p＝0.001) scores.

Conclusions: Reproductive factors including age at menarche, age at menopause and reproductive lifespan were related to motor symptoms, non-motor symptoms and quality of life in PD, but not related to age at onset.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/female-reproductive-factors-and-clinical-features-of-pd/