Objective: To identify factors correlated with life satisfaction among patients with Parkinson’s disease in Mexico.

Background: Parkinson’s disease motor and non-motor symptoms have been the main focus of research for years; nonetheless, mental health is also a factor to consider in quality of life, included in WHO definition’s of health.[1,2] Life satisfaction is an integral part of subjective well-being but isn’t included in the traditional medical model, even though it has repercussions in quality of life and disease outcomes.

Method: A cross-sectional analytical study was conducted with 80 patients with PD, from two Movement Disorders Clinics in Mexico. The Spanish version of the Satisfaction with Life Scale (SWLS) was utilized as the outcome measure.[3][4] A multivariate regression analysis was conducted to identify predictors of SWLS scores in our cohort.

Results: The age of our cohort was of 65.1 (12.3) years, with age at diagnosis of 58.9 (13.1) years, disease duration of 8.9 (8.2) years, HY stage score of 2.6 (0.6), and MDS-UPDRS part III off medication score of 35.1 (14.2). The analysis showed that the SWLS score of patients with recreational/social activities was significantly higher than those without these activities (27.9 vs. 25.0, r_pb=.230, p=.040), and was significantly higher in patients not receiving levodopa/carbidopa than in those receiving this medication (25.0 vs. 28.6, r_pb=.271, p=.015). SWLS score was significantly higher in patients living in the west and northeast regions than in those not living in these regions (h2=.203, p = .009). A weak positive correlation was observed between age (r=.261, p=.020), education (r=.264, p=.018), age at diagnosis (r=.259, p=.023), and S&E (r=.322, p=.012) with SWLS scores. A weak negative correlation was noted between the MDS-UPDRS part II score (r=−.269, p=.038) and SWLS scores. We developed a model to predict SWLS scores, where DBS, geographic region, education, and Negative Affect Schedule score, were found to be significant predictors of SWLS scores. The final model had an R² of 0.557 (p<.001), Table 1.

Conclusion: Our results suggest that patient’s recreational and social activities, dopaminergic drugs, their living geographic region, age, education, and their capability on activities on daily living may have an impact on life satisfaction. We found that factors such as DBS, geographic region, education, and negative affect predict patient’s satisfaction with life.

References: 1.- Kalia LV, Lang AE. Parkinson’s disease. Lancet. 2015;386(9996):896-912. 2.- World Health Organization. (2014). Basic Documents. 19/01/2020, de WHO Sitio web: http://apps.who.int/gb/bd/PDF/bd48/basic-documents-48th-edition-en.pdf#page=1 3.- Diener E, Emmons RA, Larsen RJ, Griffin S. The Satisfaction With Life Scale. J Pers Assess. 1985;49(1):71-5. 4.-Vazquez C, Duque A, Hervas G. Satisfaction with life scale in a representative sample of Spanish adults: validation and normative data. Span J Psychol. 2013;16:E82.

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