Objective: The aim of this study was to estimate the prevalence of FOG (FOG), and to identify factors that independently contribute to FOG in patients with Parkinson’s disease (PD).

Background: FOG is a common and debilitating problem in patients with PD.

Methods: We included 157 PD patients. FOG was assessed using the Freezing of Gait Questionnaire (FOG-Q). Patients with or without FOG were defined by item-3 of the FOG-Q.

Results: One hundred and eleven (70.7%) out of 157 PD patients reported FOG. Patients with FOG were older age, had long disease duration, were taking higher dose of dopaminergic agents, and had higher motor and non-motor scores than those without FOG. Multivariate linear regression analysis showed that higher modified Hoehn-Yahr (mHY) stage, Unified Parkinson’s Disease Rating Scale (UPDRS) part II score, and Non-Motor Symptom assessment scale for PD (NMSS) total score were significant predictors of the higher FOG-Q score. Patients with FOG had significantly higher scores for the cardiovascular, gastrointestinal tract, urinary, and miscellaneous domains of NMSS than those without FOG.

Conclusions: FOG in PD was associated with higher mHY stage, UPDRS part II score, and total NMSS score. Therefore, clinicians should consider the non-motor features as well as motor and ADL states in the proper management of FOG.

References: 1. Giladi N, Tal J, Azulay T, Rascol O, Brooks DJ, Melamed E, Oertel W, Poewe WH, Stocchi F, Tolosa E. Validation of the freezing of gait questionnaire in patients with Parkinson’s disease. Mov Disord 2009;24(5):655-661. 2. Moore O, Peretz C, Giladi N. Freezing of gait affects quality of life of people with Parkinson’s disease beyond its relationships with mobility and gait. Mov Disord 2007;22(15):2192-2195.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/factors-associated-with-freezing-of-gait-in-patients-with-parkinsons-disease/