Objective:

To describe the nature of premature ejaculation (PE) in a series of male patients with Parkinson’s disease (PD), with recent complaints of PE that began after the onset of PD.

Background:

PE is one of the most common symptoms of male sexual dysfunction and a source of significant distress for men and their partners. Sexual dysfunction is a common non-motor symptom in PD among which erectile dysfunction (ED) and sexual dissatisfaction are the most common. While PE affects 51.4% of male PD patients, it has not been thoroughly described and studied in the context of PD.

Methods:

We describe eight male patients with clinically diagnosed PD, who complained of a sudden inability to control ejaculation. They were diagnosed with PE by the sex therapy specialist of the clinic. 

Clinically and sexually related data was collected, including age at PD onset, history of pharmacotherapy for PD [age at levodopa and/or dopamine agonists (DA) initiation, current treatment, and levodopa and/or DA daily dose at PE onset], the age at PE onset, previous and present intravaginal ejaculation latency time (IELT), coexisting sexual dysfunctions.

Results:

The mean age was 62.6 ±12.0 years, range: 45-85 years. The mean age at PD onset was 53.3 ± 12.7 years (range 38-77 years). PE appeared in all cases after anti-PD treatment initiation with a mean age of 57.3 ± 12.4 years, and 4.0 ±3.3 (range 0-9) years following PD diagnosis. The characteristics of PE were variable: all patients had an ejaculation latency of less than 2 minutes. Six patients reported on severe and extreme PE (anteportal or immediate ejaculation), characterized by a feeling of loss of control, and occurring after short physical stimulation. All cases reported on longer IELT prior to anti-parkinsonian treatment initiation and PE onset.  

Conclusions:

In this serial case series in PD patients, PE was severe with an extremely short and disabling IELT. The common denominator of these patients was the sudden onset of PE, and its severe nature, in men who have not suffered from ejaculatory problems before the onset of PD treatment. We suggest that it may be related to dopaminergic agents and not to the disease per se. Since PE has such a profound impact for both men and their partners, active inquiry about this disturbing phenomenon is recommended.

« Back to 2017 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/extreme-premature-ejaculation-in-parkinsons-disease/