Category: Parkinsonism, Atypical: MSA
Objective: In this study, we investigated the differences in exosomal α-syn between MSA and PD patients.
Background: Parkinson’s disease (PD) and multiple system atrophy (MSA) are both neurodegenerative diseases. The abnormal accumulation of α-synuclein (α-syn) in neurons and glial inclusions is the main pathophysiological feature of these diseases. Recently, the role of exosomal α-syn in the pathogenesis of MSA and PD had attracted considerable attention. However, the difference of exosomal α-syn from MSA and PD patients remains unclear.
Method: Plasma-derived exosomes were isolated from MSA and PD patients. Then, exosomes were injected into the unilateral striatum of mice using stereotaxic apparatus for 3 months. In this study, we tested the seeding activity of MSA and PD exosomes and their roles in the α-syn aggregation in the bladders of mice.
Results: The increased seeding activity (Figure 1) and α-syn aggregation in the bladders of mice (Figure 2) were found in mice injected with MSA exosomes compared to those injected with PD exosomes.
Conclusion: Collectively, our results suggest that exosomal α-syn from MSA and PD patients has a distinct effect on the pathology in vivo, and might provide a mechanistic explanation for the different clinical symptoms of MSA and PD patients.
To cite this abstract in AMA style:
X. Chi, L. Kou, Y. Sun, Y. Xia, T. Wang. Exosomal α-synuclein in Multiple system atrophy and parkinson’s disease cause distinct synucleinopathies [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/exosomal-%ce%b1-synuclein-in-multiple-system-atrophy-and-parkinsons-disease-cause-distinct-synucleinopathies/. Accessed September 7, 2024.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/exosomal-%ce%b1-synuclein-in-multiple-system-atrophy-and-parkinsons-disease-cause-distinct-synucleinopathies/