Session Information
Date: Tuesday, June 6, 2017
Session Title: Parkinson's Disease: Pathophysiology
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: This paper research the intervention effect of the different intensity treadmill exercise on motor function of Parkinson ‘s diseases (PD) model rats,and explore the most suitable intensity treadmill exercise intervention for prevention and treatment of PD.
Background: Parkinson disease (PD) is the second most common progressive, irreversible neurodegenerative disorder in theWorld.Leads to difficulty with activities of daily living (ADLs) and decline in quality of life (QOL). Treatment options for PD are limited to pharmacologic management and surgery.Less invasive alternatives, such as exercise, have captured the attention of scientists and clinicians as possible adjunctive therapy.
Methods: Clean level male SD rats were randomly divided into Control group,PD group,PD+6Ex group,PD+11Ex group and PD+16Ex group. PD model rats were established by injection of 6-OHDA in right medial forebrain bundle single point,Control groups rats received same dose of saline.The exercise groups were intervened by 4 weeks of treadmill exercise at 24 hours after the surgery,the corresponding running speed of each group is 6m/min,11m/min and 16m/min,30 min/day,5day/week.
Results: Cylinder test showed that,the effect of the intervention became more and more obvious with the time prolonged.Grid test results showed,after 4 weeks exercise intervention,compared with PD group of rats,the slip times of PD+11Ex group significantly reduced.Immunohistochemical results showed that,compared with PD group,the expression of TH and D2DR in striatum of PD+11Ex group and PD+16Ex group ratsincreased significantly .The variation trend of the results of Western Blot was in accordance with the results of immunohistochemistry. The expression levels of TH and D2DR in striatum in low intensity exercise group rats have low correlations with the changes of motor ability ;but in medium intensity exercise group rats have high correlations with the changes of motor ability。
Conclusions: 4 weeks treadmill exercise intervention can reduce movement dysfunction of PD model rats, and significantly increased TH and D2DR expression level in striatum.This suggests that DA systems involved in the regulation of motor function in rats; and the neurobiological mechanisms of exercise intervention reduced the motor dysfunction in PD model rats may related to the regulation effect of TH and D2DR..
References: Kim SN,Doo AP,Park JY,et al. Combined treatment with acupunctuncture reduces effective dose and alleviates adverse effect of L-dopa by normalizing Parkinsons diease induced neurochemical imbalance[J]. BrainRes,2014,1544:33-44.
Lamotte G,Rafferty MR,Prodoeh IJ,et al. Effects of endurance exercise training on the motor and non-motor features of parkinson’s disease:a review[J]. J Parkinson’s Dis,2015,5(1):21-41.
To cite this abstract in AMA style:
x. Liu, p. Chen, d. Qiao, m. wang. Effects of different intensity exercises on motor function of PD rats as well as the regulation of DA [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/effects-of-different-intensity-exercises-on-motor-function-of-pd-rats-as-well-as-the-regulation-of-da/. Accessed January 18, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/effects-of-different-intensity-exercises-on-motor-function-of-pd-rats-as-well-as-the-regulation-of-da/