Objective: To evaluate the effect of lower level laser therapy for neurogenic or non-neurogenic overactive bladder (OAB)

Background: There are many patients with OAB in the world and OAB is complained in most of the patients with not only urological or gynecological diseases but also neurological diseases. Various medications and invasive therapies have been established recently because of unmet needs in OAB. However, therapy for OAB, in particular for neurogenic overactive bladder, has been limited yet because of adverse effect, insufficient effect and so on.

Method: Fifteen patients with the patients with neurogenic or non-neurogenic OAB were recruited and were randomly assigned to receive either a lower level laser therapy (Laser group: N=7) or a placebo therapy without laser radiation (Pseudo group: N=8). Laser irradiation was administered for 5 minutes at a time and twice a week for 6 weeks to the skin over each side of the L3 lumbosacral intervertebral foramen. We performed questionnaires of lower urinary tract symptom and adverse effect, frequency-urine volume charts, urodymanic studies (UDSs) before and 6 weeks after these therapies.

Results: Urinary urgency (P<0.002), OAB symptom score (P<0.006), maximum bladder capacity (P<0.007), bladder volume at stat of detrusor overactivity (P<0.042) and so on were significant improved in laser group. Symptoms associated with voiding and voiding function in UDSs were unchanged in both groups. There are no patients with adverse effect in both groups.

Conclusion: Lower level laser therapy may be safety and effective therapy for neurogenic or non-neurogenic OAB.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/effect-of-lower-level-laser-therapy-for-neurogenic-or-non-neurogenic-overactive-bladder/