Objective: To emphasize the dry eye diseases in Parkinson’s disease patients

Background: In a patient with dry eye, ocular surface could have local inflammation and damage; severe cases could have a bad quality of life. As neurosensory abnormality is one of the potential determinants, this review focuses on the importance and association between dry eye disease (DED) and Parkinson’s Disease (PD).

Method: Literature Review

Results: Dry eye has been prevalent in 53 to 60 percent of patients with PD of any severity level. Many mechanisms cause dry eye diseases in PD patients including aqueous deficient, evaporative, tear fluid dysfunction, and iatrogenic dry eye diseases. It has been reported in PD patients as suggested by the decreased Schirmer’s score, reduced blink rate, reduced corneal sensitivity, rapid tear breakup time, increased meibomian gland dysfunction, tear film hyperosmolarity, reduced central corneal thickness and abnormal alpha-synuclein proteins in tear fluid. Iatrogenic dry eye could be a consequence of PD medication and deep brain stimulation.

Conclusion: Dry eye is not uncommon among PD patients, could worsen the quality of life and should be treated and prevented.

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