Objective: The aim of this study is to examine whether intestinal microbiota correlate with progression of clinical severity and serum inflammation marker.

Background: Constipation is the most common premotor symptom in Parkinson’s disease (PD). As the intestinal microbiota is likely to have a marked effect on the hyperpermeability-induced oxidative stress, It may be causally associated with α-synuclein pathology in the enteric nervous system in PD. We reported changes in the intestinal microbiota between PD patients and healthy controls(Hasegawa S, PLos One 2015). Hasegawa S, Goto S, Tsuji H, et al. Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s disease. PLoS One 2015;10:e0142164.

Methods: We analyzed the relation between microbiota, serum samples and the clinical progression of clinical symptom from 40 PD subjects who have been able to follow up for two years. The serum level of lipopolysaccharide-binding protein (LBP), IL-6, TNF-α, Leptin and Ghrelin were measured. We counted the number of 19 bacterial groups/genera/species by RT-quantitative PCR of bacterial 16S or 23S rRNA. Clinical features were measured using UPDRS and other non-motor symptom.

Results: Deterioration of clinical symptoms (over 15 point UPDRS score) was found in 15 patients. There were no significant difference in inflammation marker between deterioration group and others. Bifidobacterium was significantly lower and Pseudomonas was higher in deterioration group than control group. The change of LBP for 2 years correlated with the number of Bifidobacterium (r=0.36) and the change of UPDRS 3 (r=0.46). The change of UPDRS3 sore negatively correlated with the sum of fecal bacterial counts, the counts of Bifidobacterium (r=0.51) and that of Bacteroides fragilis group (r=0.53).

Conclusions: The count of Bifidobacterium was depleted from deterioration group, which suggests that decrease of Bifidobacterium affects pathology progress in Parkinson’s disease. The high abundance of Pseudomonas which is aerobic bacterium is a particular feature of deterioration group in spite of anaerobic environments in the intestinal tract. Theses results suggested intestinal dysbiosis may lead to the increased deterioration of clinical symptoms.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/differences-of-gut-bacterial-community-relate-to-pathology-progress-in-parkinsons-disease/