Objective:

Tha aim of the study was to determine the relationship between the development of non-motor symptoms in the development of motor deficitis in patients with PD. 

Background:

Non-motor symptoms can vary substantially from patient to patient. Non-motor symptoms dominate the clinical picture of advanced Parkinson’s disease and contribute to severe disability, impaired quality of life, and shortened life expectancy

Methods: The study involved 37 patients aged 53 to 68 years (mean age 57±2,3) and devided into  2 groups. 1-group 14 patients with of PD, aged 63±3,2), 2-group  23 patients aged 58±2,8 with Parkinson symdrome of vascular genesis. Disease duration ranged from 3 to 5 years. Patients were followed up for 2 years examining clinic-anamnestic and cognitive disorders analysis with comparing movement disorders. MRI and dopplerography of extra and intracranial vessesls were used to produce reliable data. 

Results: At 1-group by MRI of brain there was not any rude focal pathology. In 71,4% patients were revealed atrophy of the cerebral cortex in frontal-parietal areas, in 28,6%  subatrophy of temporal and occipital regions of brain. Out of cognitive disorders revealed declination of short-term memory at 92,9% , long-term memory was suffered in all 100% patients, thinking ability at 85,7%, speech at 92,9%, depression at 100% relatively. During clinic monitoring, declination of thinking ability increased hypokinesia at 48%, tremor at 43%, speech disorders lead to gain rigidity at 68%, memory reduction lead to gait disorders at 63,4%, such changes lead to aggravation of depressive state in all 100% patients. In patients of  2 –group  by MRI  was revealed fine sites of ischemia at 52,3%, with all this going on suffered short-term memory and revealed a slight depression, one-sided limb tremor, light hypokinesia, slightly increased diffusive tremor.  Local encephalomalacia and leukoariosis were revealed at 21,6%, out of it cognitive disorders and depression were not detected in that intensity as in 1-group, but tremor of limbs and lower jaw, hypokinesia, hypomimia, speech disorders were so well developed. 

Conclusions:

Hence, movement disorders might be in direct proportion to cognitive disorders in Parkinson disease,  while movement disorders develops out of proportion to cognitive disorders in Parkinson syndrome.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/correlation-and-impact-of-non-motor-symptoms-on-intensity-of-motor-symptoms-in-parkinsons-disease/