Session Information
Date: Monday, June 5, 2017
Session Title: Surgical Therapy: Parkinson’s Disease
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To determine whether the precise location of stimulation affects cognitive performance and mood.
Background: Deep brain stimulation of the subthalamic nucleus effectively treats the motor symptoms of Parkinson disease. The cognitive and behavioral changes that can accompany this treatment are often hypothesized to arise from current spread from the intended sensorimotor (dorsal/lateral/posterior) division of the nucleus to the associative and limbic (ventral/medial/anterior) divisions.
Methods: Anatomical coordinates of 73 active electrode contacts (32 right; 41 left) were determined for 46 patients with idiopathic Parkinson disease treated with deep brain stimulation. Contact locations were then correlated with post-surgical changes in neuropsychological performance and depression ratings.
Results: A significant association existed between improved depression and more medial contact locations in the left hemisphere. Semantic fluency decline, the most commonly reported cognitive change, was also associated with more medial contacts in the left hemisphere. Phonemic fluency deterioration, on the other hand, was related to more posterior placement on the left. Finally, worsened single trial learning was not associated with contact location but did show a relationship with stimulation voltage in the right hemisphere.A significant association existed between improved depression and more medial contact locations in the left hemisphere. Semantic fluency decline, the most commonly reported cognitive change, was also associated with more medial contacts in the left hemisphere. Phonemic fluency deterioration, on the other hand, was related to more posterior placement on the left. Finally, worsened single trial learning was not associated with contact location but did show a relationship with stimulation voltage in the right hemisphere.
Conclusions: These data suggest that specific cognitive and mood outcomes are influenced by stimulation location and parameters.
To cite this abstract in AMA style:
D. Floden, C. Matias, C. Wathen, G. Ozinga, O. Hogue, A. Machado. Contact location and non-motor outcomes in subthalamic nucleus deep brain stimulation for Parkinson’s disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/contact-location-and-non-motor-outcomes-in-subthalamic-nucleus-deep-brain-stimulation-for-parkinsons-disease/. Accessed May 10, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/contact-location-and-non-motor-outcomes-in-subthalamic-nucleus-deep-brain-stimulation-for-parkinsons-disease/