Objective: The study of cognitive impairment was a combination of neurological and electroencephalographic techniques that allowed us to objectify pathogenetic features of Tourettes syndrome and a differentiated approach to drug therapy.

Background: Tics is the dominant form of hyperkinesis in children. The prevalence of tics child population is up to 6%. Tourette syndrome, occurs in 0.1% of cases and is characterized by multiple motor and vocal tics. It is Proved that the close relationship between the motor disorders and attention deficit. In connection with the accompanying tics, violation of attention, memory, decreased ability to think abstractly learning difficulties were revealed in 60-70% of these patients.

Methods: We studied 331 children to explore the semiotics of cognitive impairment in patients with tics and Tourette’s syndrome. it was also compared the topography of cortical dysfunction with indicators electroencephalographic mapping biorhythms brain. it has been studied the effects of haloperidol and tiapride on cognitive function. To assess the effectiveness and encephabol semax in therapy of cognitive impairment in patients with tics and Tourette’s syndrome.

Results: It was found that during the period of acute illness disruption of the function of memory, attention, reading and writing were revealed and disruption mainly localized in the fronto-temporal region of the dominant hemisphere. It was found that in patients with hereditary disorders ticks resistant auditory-verbal memory and reading correlate with the spectral power of the theta band in the temporal region of the dominant hemisphere, disorders of attention and memory – with high spectral power of the theta range in the frontal area of the dominant hemisphere.

Conclusions: In patients with tic disorders cognitive impairments were identified with different severity depending on the severity of tics with topical localization the fronto-temporal areas of the dominant hemisphere. Cortical dysfunction fronto-temporal areas of the dominant hemisphere topically correlates to the pathological EEG rhythms. Combination therapy with neuroleptics and encephabol were effective in patients with tic disorders.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-impairments-in-children-with-tic-disorders-and-tourette-syndrome/