Objective: We aimed to determine how the cognitive domains affect quality of life (QoL) in different cognitive states in PD.

Background: Parkinson’s disease with mild cognitive impairment (PD-MCI) or dementia (PDD) has been shown to be correlated with poor QoL. The association between specific cognitive domains and QoL is less clear.

Method: We recruited 600 PD patients, including 185 PD patients with normal cognition (PD-NC), 336 PD-MCI patients, and 79 PDD patients. All patients underwent a scale-based assessment (PDQ-39) for QoL, as well as clinical evaluations and neuropsychological tests.

Results: QoL was more impaired across the three groups (PD-NC < PD-MCI < PDD). Generalized linear model revealed that no neuropsychological test was significantly associated with QoL in PD-NC group; neuropsychological tests in attention and language domains were significantly associated with QoL in PD-MCI patients; neuropsychological tests in memory and language domains were significantly associated with QoL in PDD patients.

Conclusion: Cognitive domains contribute differently to QoL in PD. These findings may prompt clinicians to target specific cognitive domains for improving QoL in the PD patients.

« Back to MDS Virtual Congress 2020

MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-function-and-quality-of-life-in-parkinsons-disease-a-cross-sectional-study/