Objective: We analysed if Impulse Control Disorders (ICDs) and/or Related Behaviors (RBs) were associated with levodopa-induced dyskinesia (LIDs) in Brazilian patients with Parkinson´s disease (PD) and compare the cognitive and psychiatric aspects of the patients with and without ICDs in our Movement Disorders Outpatient Clinic at Universidade Federal de São Paulo.

Background: ICDs and/or RBs and LID are broadly recognized complications in PD. Studies have identified an increased probability of ICDs and LIDs co-ocurrence and suggest that motor and non-motor side-effects of dopamine replacement therapy might be associated with a common underlying susceptibility.

Method: 65 consecutive PD patients age < 60y, at the time of the clinical evaluation,, were assessed with Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), Clock Drawing Test (CDT), Hopkins Verbal Learning Test-Revised (HVLT-R), Trail Making Test A (TMT-A) and B (TMT-B), Forward Digit Span (FDS) and Backward Digit Span (BDS), Stroop Test (ST), Beck Depressive Inventory (BDI), Neuropsychiatric Inventory (NPI), PD Impulsive-Compulsive Disorders Questionnaire – Current Short (QUIP-CS) Portuguese version, Barratt Impulsiveness Scale – (BIS 11), UPDRS-3,HY and UDysRS.

Results: The study group showed a mean age ± SD of 50,6 ± 6,4 y, 63,1%(41) were men, 61,5% patients were taking dopaminergic agonist , the mean PD duration ± SD was 7,9 ± 5y, the mean LEDD± was 784±440mg, the mean UPDRS-3± SD and UDysRS were 26,4 ± 12,9 and 16,6 ±0,4 ,respectively. The prevalence of ICD and/or RB in this group was 55%. Patients were distributed in 2 groups (with ICD and/or RBs and without ICD and/or RBs). LEDD were higher in ICD group (869,5± 416,2 vs 677,9± 525,0, p= 0,02), UDysRS historical section part 2 (Off-Dystonia) scores were higher in ICD group (4,9± 3,0 vs 2,4± 4,4, p= 0,03). There was no association between the presence of ICDs and/or RBs with LID ( X² =2,8, p=0,093) and PD duration was associated with the presence of LID ( X² =19,4, p< 0,001) but not with ICD and/or RBs  (X² =1,9, p=0,384).

Conclusion: Our study found association between ICDs and/or RBs with Off-Dystonia scores, PD duration was associated with LID but not with ICDs and/or RBs. ICDs and/or RBs and LID were associated with LEDD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/cognitive-and-motor-aspects-of-a-brazilian-population-with-parkinsons-disease-and-impulse-control-disorders-and-or-related-behaviors-an-observational-study/